Follow Us:

social twitter box white 32 social facebook box blue 32social linkedin box blue 32YoutubeISN Blog

Monday, 19 September 2016 10:52

Cochrane Library: Interventions for preventing the progression of autosomal dominant polycystic kidney disease

By 
Rate this item
(0 votes)

Cochrane Library: Interventions for preventing the progression of autosomal dominant polycystic kidney disease

Introduction

Introduction

Autosomal Dominant Polycystic kidney disease (ADPKD) is the most common inherited kidney disorder leading to end-stage kidney disease requiring dialysis treatment or transplantation. This disease is mainly characterized by uncontrolled growth of cysts with renal parenchyma injury, compression, and fibrosis. Increases in cyst numbers and size over time cause clinical complications such as infections, bleeding, flank pain, hypertension and, ultimately, a progressive loss in renal function. Recently, major advancements have been made in the biological understanding of the cellular pathways involved in cyst growth. Yet, therapeutic management of patients with ADPKD remains confined to symptom management and disease complications such as hypertension, urinary infections and flank pain. The main aim of this Cochrane review was to summarize the benefits and harms of therapeutic interventions directed at preventing progression of ADPKD. The Cochrane review included 30 studies among about 2000 patients. Despite numerous potential treatments targeting disease pathogenesis, evidence from clinical trials is currently sparse or limited. At present there is no evidence that pharmacological interventions prevent end-stage kidney disease or mortality.

0 Evidence summary

Authors

davide

Davide Bolignano

Davide is a nephrologist working as clinical researcher and epidemiologist at the Institute of Clinical Physiology of the Italian National Research Council (CNR) in Reggio Calabria, Italy. His fields of interest and research are the epidemiology, physiology, and pathophysiology of kidney diseases.

palmer

Suetonia Palmer

Suetonia is a nephrologist based at the University of Otago, Christchurch in New Zealand, and who trained in New Zealand and the USA. She is an Editor and Podcast Editor for Cochrane Kidney and Transplant.

 

Copyright© 2016 Cochrane Kidney and Transplant. Published by John Wiley & Sons, Ltd.

Additional Info

  • Language: English
  • Contains Audio: Yes
  • Content Type: eLearning modules
  • Source: Cochrane
  • Year: 2016
  • Members Only: No
Read 2564 times Last modified on Tuesday, 04 October 2016 06:37
Cochrane Kidney and Transplant

Cochrane is a global independent network of health practitioners, researchers, patient advocates and others, responding to the challenge of making the vast amounts of evidence generated through research useful for informing decisions about health. 

Follow us on Twitter: @CochraneKidney

Website: www.kidneyandtransplant.cochrane.org

Global Operations Center

Rue des Fabriques 1
1000 Brussels, Belgium
Tel: +32 2 808 04 20
Fax: +32 2 808 4454
Email contact

               

Americas Operations Center

340 North Avenue 3rd Floor
Cranford, NJ 07016-2496, United States
Tel: +1 567 248 9703
Fax: +1 908 272 7101
Email contact