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Monday, 19 September 2016 10:52

Cochrane Library: Interventions for preventing the progression of autosomal dominant polycystic kidney disease

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Cochrane Library: Interventions for preventing the progression of autosomal dominant polycystic kidney disease



Autosomal Dominant Polycystic kidney disease (ADPKD) is the most common inherited kidney disorder leading to end-stage kidney disease requiring dialysis treatment or transplantation. This disease is mainly characterized by uncontrolled growth of cysts with renal parenchyma injury, compression, and fibrosis. Increases in cyst numbers and size over time cause clinical complications such as infections, bleeding, flank pain, hypertension and, ultimately, a progressive loss in renal function. Recently, major advancements have been made in the biological understanding of the cellular pathways involved in cyst growth. Yet, therapeutic management of patients with ADPKD remains confined to symptom management and disease complications such as hypertension, urinary infections and flank pain. The main aim of this Cochrane review was to summarize the benefits and harms of therapeutic interventions directed at preventing progression of ADPKD. The Cochrane review included 30 studies among about 2000 patients. Despite numerous potential treatments targeting disease pathogenesis, evidence from clinical trials is currently sparse or limited. At present there is no evidence that pharmacological interventions prevent end-stage kidney disease or mortality.

0 Evidence summary



Davide Bolignano

Davide is a nephrologist working as clinical researcher and epidemiologist at the Institute of Clinical Physiology of the Italian National Research Council (CNR) in Reggio Calabria, Italy. His fields of interest and research are the epidemiology, physiology, and pathophysiology of kidney diseases.


Suetonia Palmer

Suetonia is a nephrologist based at the University of Otago, Christchurch in New Zealand, and who trained in New Zealand and the USA. She is an Editor and Podcast Editor for Cochrane Kidney and Transplant.


Copyright© 2016 Cochrane Kidney and Transplant. Published by John Wiley & Sons, Ltd.

Additional Info

  • Language: English
  • Contains Audio: Yes
  • Content Type: eLearning modules
  • Source: Cochrane
  • Year: 2016
  • Members Only: No
Read 4577 times Last modified on Tuesday, 04 October 2016 06:37

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