Friday, 13 February 2015 18:53

Immunity unmasks APOL1 in collapsing glomerulopathy

By  Bairbre McNicholas
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Collapsing glomerulopathy predominantly afflicts patients of African ancestry, often first presenting after the immune system is engaged by another disorder. Nichols et al. now show that collateral induction of pathogenic APOL1 allelic variants in podocytes by the ongoing immune response may be the long-sought-after explanation for the development of collapsing glomerulopathy in these patients.

 

Authors: Bairbre A McNicholas and Peter J Nelson

Reference: Kidney Int 87: 270-272; doi:10.1038/ki.2014.325

Additional Info

  • Language: English
  • Contains Audio: No
  • Content Type: Articles
  • Source: KI
  • Year: 2014
  • Members Only: No
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