×

Warning

JUser: :_load: Unable to load user with ID: 151

 


Sunday, 06 April 2014 21:28

Estimating GFR using serum beta trace protein accuracy and validation in kidney transplant and pediatric populations

By 
Rate this item
(1 Vote)

The limitations of estimates of glomerular filtration rate (GFR) based only on serum creatinine measurements have spurred an interest in more sensitive markers of GFR. Beta-trace protein (BTP), a low-molecular-weight glycoprotein freely filtered through the glomerular basement membrane and with minimal non-renal elimination, may be such a marker. We have recently derived two GFR estimation equations based on BTP. To validate these equations, we measured BTP and the plasma clearance of 99mTc-DTPA in 92 adult kidney transplant recipients and 54 pediatric patients with impaired kidney function.

 

GFR was estimated using the serum creatinine–based Modification of Diet in Renal Disease (MDRD) Study equation for adults, the Schwartz and updated Schwartz equations in children, and 4 novel BTP-derived equations (our 2 equations and 2 proposed by Poge). In adults, our BTP-based equations had low median bias and high accuracy such that 89–90% of estimates were within 30% of measured GFR. In children, the median bias of our 2 equations was low and accuracy was high such that 78–83% of estimates were within 30% of measured GFR. These results were an improvement compared to the MDRD and Schwartz equations, both of which had high median bias and reduced accuracy. The updated Schwartz equation also performed well.

 

Authors: Christine A White, Ayub Akbari, Steve Doucette, Dean Fergusson, Naser Hussain, Laurent Dinh, Guido Filler, Nathalie Lepage and Greg A Knoll

Reference: Kidney International 76: 784-791; Published online, 22 July 2009; doi:10.1038/ki.2009.262

Additional Info

  • Language: English
  • Contains Audio: No
  • Content Type: Articles
  • Source: KI
  • Year: 2014
  • Members Only: No
Read 2613 times Last modified on Tuesday, 30 December 2014 00:02

Global Operations Center

Avenue des Arts 1-2
1210 Brussels, Belgium
Tel: +32 2 808 04 20
Fax: +32 2 808 4454
Email contact

               

Americas Operations Center

340 North Avenue 3rd Floor
Cranford, NJ 07016-2496, United States
Tel: +1 567 248 9703
Fax: +1 908 272 7101
Email contact