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Wednesday, 27 April 2016 10:17

Clinical Research: The effect of HIV infection on the management of renal failure among patients undergoing peritoneal dialysis

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image ndolvuName: Kwazi Celani Zwakele Ndlovu

Hospital / Affiliation: University of KwaZulu Natal

Home Country: South Africa

Host Country: South Africa

Year: 2012

Status of your program: IN PROGRESS


Title of the project: 

The effect of HIV infection on the management of renal failure among patients undergoing peritoneal dialysis


Chronic Kidney Disease / Peritoneal dialysis 


Short description of the project or abstract: 

Renal failure is a recognised important contributor to mortality as well as morbidity associated with HIV infection either directly as in HIV associated nephropathy or as a co-morbid condition related to other chronic diseases. International experience has shown that HIV positive patients can be dialyzable and transplantable. However, in developing countries renal replacement therapy, particularly hemodialysis, is not widely available due to limited financial and human resources. Continuous ambulatory peritoneal dialysis (CAPD) in low to middle income countries like South Africa can be a valuable renal replacement tool due to its relative ease of use. This study explores the outcomes of CAPD as well as associated complications in the HIV infected dialysis requiring renal failure population. This prospective cohort study was started in September 2012 and by February 2015 had recruited the targeted 70 HIV negative and 70 HIV positive renal failure patients who underwent dialysis with newly inserted Tenckhoff catheters in our unit. All patients are followed-up at monthly intervals at a central renal clinic for 18 months or until the primary endpoints of catheter failure or mortality were reached. End of data collection is expected by July 2016.


Learning or Research objectives:

  • To evaluate the effects of HIV positivity on outcomes of CAPD (catheter patency and mortality primarily) among dialysis requiring renal failure patients
  • To evaluate the effects of HIV positivity on risk factors, pattern and incidence of catheter related complication
  • To assess the effects of HIV positivity on the S. aureus nasal carriage and incidence of catheter related infection among renal failure patients undergoing peritoneal dialysis
  • To examine the presence and significance of HIV virus particles in peritoneal dialysis fluid in HIV positive patients treated with CAPD



Additional Info

  • Year: 2012
  • Status: In progress
  • Partners: ISN only
  • Region: Africa
  • Country: South Africa
  • Topics: CKD, Peritoneal Dialysis
Read 6516 times Last modified on Wednesday, 27 April 2016 10:36

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