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Wednesday, 27 April 2016 14:43

Clinical Research: Epidemiology of Acute Kidney Injury at intensive care units (ICUs) in Alexandria teaching hospitals

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image SamarName: Samar Abd ElHafeez

Hospital / Affiliation: High Institute of Public Health - Alexandria University

Home Country: Egypt

Host Country: Egypt

Year: 2016

Status of your program: IN PROGRESS



Title of the project: 

Epidemiology of Acute Kidney Injury at intensive care units (ICUs) in Alexandria teaching hospitals


Acute Kidney Injury 


Short description of the project or abstract:

AKI is an escalating health problem, both in the developed and developing countries, and particularly in Africa no large studies were specifically designed to assess the burden and risk factors of this disease. AKI is notoriously associated with high morbidity and mortality especially among hospitalized patients, with high social and economic costs. Egypt is one of the most populous countries in Africa and Alexandria is the second largest city in the Country. To our knowledge there is no specific information available about the rate of community and hospital acquired AKI at ICUs in Alexandria and only sparse data exist about etiological and prognostic factors of AKI in Africa.
Thus, a well powered, appropriately designed, prospective observational study conducted at ICUs of the Alexandria teaching hospitals represents a unique opportunity to gain knowledge about the frequency, risk factors and outcomes of AKI in Northern Africa, a macro-area where the prevalence of CKD has already reached levels comparable to those in Europe and in the USA . It was reported that the pooled prevalence of CKD among general population was 30% in North Africa. This study specifically aims at investigating the burden, risk factors/predictors, and outcome of AKI as a public health problem among critically ill patients. Recruitment of the patients will last for six months. Those who fulfill the definition of AKI based on KDIGO will be enrolled into the study. They will be followed until hospital discharge to determine the different outcomes associated with AKI. We foresee that the findings in our study may serve as an organizational model and knowledge basis for extending the recognition of the burden of AKI in other urban areas in Africa and to track patient outcomes and hopefully set a basis to reduce the burden of AKI in similar health-contexts.


Learning or Research objectives:

The overall aim is to investigate the problem of Acute Kidney Injury and its consequences at Intensive Care Units of Alexandria teaching hospitals Specific aims:

  • Establish a clear, systematic, affordable organizational model for the detection of the burden of AKI in a large urban area in Northern Africa. This model may serve as a flexible basis for the recognition of AKI in other health context in Africa
  • Assess the frequency of AKI (community and hospital acquired) at ICUs of Alexandria teaching hospitals. KDIGO criteria will be adopted as a main method for the diagnosis of AKI but complementary information will be collected to allow application of alternative definitions of AKI like AKI defined on the basis of RIFLE and AKIN criteria
  • Identify etiological and prognostic factors associated with the occurrence of AKI 
  • Determine the different outcomes of patients with AKI
  • Produce an evidence basis for local guidelines aimed at the prevention of AKI in large urban centers in Africa


Additional Info

  • Year: 2016
  • Status: In progress
  • Partners: ISN only
  • Region: Africa
  • Country: Egypt
  • Topics: AKI
Read 6972 times Last modified on Thursday, 27 July 2017 07:20

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