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Thursday, 19 May 2016 13:24

Clinical Research : Study on the long term renal outcome of pediatric patients admitted in pediatric intensive care unit and post cardiac surgery

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image sethiName: Sidharth Kumar Sethi

Hospital / Affiliation: MEDANTA, THE MEDICITY

Home Country: INDIA

Host Country: INDIA

Year: 2016

Status of your program: GRANT ACCEPTED

 

 

Title of the project: 

Study on the long term renal outcome of pediatric patients admitted in pediatric intensive care unit and post cardiac surgery

Topics: 

Chronic Kidney Injury, Acute Kidney Injury, Pediatric Nephrology

 

Short description of the project or abstract:

The epidemiology of pediatric acute kidney injury (pAKI) has transformed in the last decades with a shift from primary kidney disease to AKI associated with systemic illnesses or their treatments in critically-ill children and neonates. Even though pAKI has been shown to be associated with poor short-term outcomes including mortality in multiple studies, the long-term renal outcomes in survivors of pAKI in the pediatric and neonatal intensive care unit (PICU/NICU) setting have been understudied and we could only find limited observational studies from PICU revealing a high prevalence of chronic renal abnormalities or chronic kidney disease (CKD) following AKI (PICU:10-69%).

Thus the purpose of this study is to explore the burden of adverse renal outcome in children aged 0-18 years after an episode of AKI in pediatric intensive care or pediatric cardiothoracic intensive care.
Study Design : Cross-Sectional Pilot
Study Duration: 1 year (Patients shall be enrolled and assessed over a period of 1 year)
Study population : All pediatric patients (aged 0-18 years) who were admitted in pediatric intensive care (PICU) or, those who underwent a cardiopulmonary bypass in the year 2012- 2014, and had AKI will be followed up.

 

Learning or Research objectives:

To find out the adverse renal outcome in pediatric patients aged 0-18 years following AKI in terms of:

  • Reduced GFR< 90 mL/min/1.73 m2
  • Hypertension
  • Proteinuria, including tubular proteinuria Significance

There are large number of patients with sequel following AKI, and since early CKD is clinically silent, with proteinuria and hypertension being two treatable complications of kidney disease, children should undergo regular urine analysis and blood pressure assessments at least annually for several years after their AKI.

 

Additional Info

  • Year: 2016
  • Status: Grant accepted
  • Partners: ISN only
  • Region: South Asia
  • Country: India
  • Topics: AKI, CKD, Paediatric nephrology
Read 7132 times Last modified on Friday, 17 February 2017 12:28

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