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Clinical Research: A study on the Tolerability, Applicability and Effectiveness of sodium bicarbonate therapy in retarding progression to End Stage Renal Disease in predialytic CKD patients

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image adewale akinsolaName: ADEWALE AKINSOLA

Hospital / Affiliation: Obafemi Awolowo University Teaching Hospital Complex, Ile-Ife, Osun State

Home Country: Nigeria

Host Country: Nigeria

Year: 2012

Status of your program: Completed 

 

 

Title of the project: 

A study on the Tolerability, Applicability and Effectiveness of sodium bicarbonate therapy in retarding
progression to End Stage Renal Disease (ESRD) in Predialytic Chronic Kidney Disease patients

Topic: 

Chronic Kidney Disease 

 

Short description of the project or abstract:

 An open label, randomised, prospective study of 75 patients with moderately severe CKD (stage 4) with established metabolic acidosis (serum bicarbonate being between 16 and 21 mmol/l, measured on 2 consecutive occasions) over a period of 24 months.
Participants were divided into 2 age - and sex-matched groups; first group received sodium bicarbonate tablets (600mg thrice daily) in addition to standard of care therapy whle the second group received standard therapy alone.
1. the progression of ckd was monitored using serial gfr (creatinine clearance) and serum creatinine levels.
2. patients' renal survival as defined by crcl <15ml/min was determined
3. impact of treatment on:
a. patients' nutritional status was evaluated with athropometric indices and serum albumin
b. renal protein excretion was determined by serial 24hr urinary protein estimation
c. calcium-phosphate metabolism and haemoglobin levels were determined by serial monitoring of serum calcium, phosphate and haemoglobin levels.
d. blood pressure and serum bicarbonate levels were also determined

These findings were compared using appropriate statistics between treated group and the controls.
Bicarbonate treatment significantly halted the progression of CKD, and also a statistically significant lower proportion of the treated patients reached end stage compared to the controls. Inspite of the observed significant rise in serum bicarbonate levels in treated patients, there was no adverse effect on blood pressure control.
There was significant increase in serum albumin in treated patients. There was no effect on mean haemoglobin levels. A higher urinary protein excretion was observed in treated patients than the controls.
No significant untowards adverse effect was observed

 

Learning or research objectives:  

  • To determine the effectiveness of sodium bicarbonate therapy in retarding progression to ESRD
  • To determine the effects of sodium bicarbonate therapy on biochemical and nutritional parameters
  • To determine the tolerability of sodium bicarbonate and adverse events that may be associated with it

 

Additional Info

  • Year: 2012
  • Status: Completed
  • Partners: ISN only
  • Region: Africa
  • Country: Nigeria
  • Topics: CKD
Read 6774 times Last modified on Friday, 17 February 2017 12:23

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