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Clinical Research: Risk factors of CKD and collaborative management of patients with CKD in China

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image Luxia ZhangName: Luxia Zhang

Hospital / Affiliation: Renal Division, Peking University First Hospital

Home Country: China

Host Country: China

Year: 2010

Status of your program: Completed 


Title of the project: 

Risk factors of CKD and collaborative management of patients with CKD in China


Chronic Kidney Disease 


Short description of the project or abstract: 

Background: Previous studies have revealed a high prevalence of chronic kidney disease (CKD) among developing countries. However, there is no national survey of CKD incorporating both estimated glomerular filtration rate (eGFR) and albuminuria in a developing country with the marked economic diversity now seen in China.

Project description: We initiated a national cross-sectional survey of CKD in China, which is partly supported by International Society of Nephrology. A multistage, stratified sampling method was used to obtain a representative sample of persons aged 18 years or older in the general population. CKD was defined as eGFR less than 60 mL/min/1.73m2 or/and the presence of albuminuria. We found that the adjusted prevalence of eGFR<60mL/min/1.73m2 and albuminuria was 1.7% (95% confidence interval [CI] 1.5%-1.9%) and 9.4% (95% CI 8.9%-10.0%), respectively.

The overall prevalence of CKD was 10.8% (95% CI 10.2%-11.3%); therefore the number of patients with CKD in China is estimated to be about 119.5 million. In rural area, an independent positive association was observed between economic development levels and the presence of albuminuria; which might be related to the increasing metabolic disorders secondary to changes of life-style, as well as suboptimal health care of metabolic disorders. Other factors independently associated with kidney damage included hypertension, diabetes, history of cardiovascular disease etc. Our study adds to the current understanding of integrated prevention and management of non-communicable diseases worldwidely, especially in the developing countries. The manuscript of main results has been published in Lancet (2012; 379: 815-822).


Learning or Research objectives:

  • Obtain the prevalence of CKD in China by using the eGFR and albuminuria
  • Assess the risk factors of CKD and provide preliminary evidence for CKD management and prevention


Additional Info

  • Year: 2010
  • Status: Completed
  • Partners: ISN only
  • Region: North and East Asia
  • Country: China
  • Topics: CKD
Read 7355 times Last modified on Tuesday, 14 June 2016 09:36

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