Monday, 06 March 2017 11:55

Clinical Research: Farming Practices as Risk Factors for CKD in Nigeria

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Ayodeji Arije

Hospital/Affiliation: University College Hospital/ College of Medicine, University of Ibadan

Home Country: Nigeria

Host Country: Nigeria

Year: started in 2016

Status of the program: IN PROGRESS

Title of the project:
Farming Practices as Risk Factors for CKD in Nigeria


Short description of the project or abstract:
Chronic kidney disease (CKD) is a global health problem, and this was attested to by its recent inclusion on the list of non communicable diseases (NCDs) demanding urgent public attention by the World Health Organization (WHO).1 It occurs in 10% of the world population.2 However, an entity called CKD of unknown cause (CKDu) is increasingly being recognized.3-5 Previously the entity called Balkan nephropathy initially presented as kidney disease of unknown cause, until it was eventually identified and linked to some environmental factors prevalent in a localized region of the world.6-9 CKD of unknown cause has also been recently described as occurring in alarming proportions in certain deprived, poor, agricultural areas of the developing world. 3, 4, 10-14  Most of those affected do not have hypertension or diabetes mellitus. Implicated factors include the use of agrochemicals, dehydration, consumption of high sugar content fluids, exposure to heavy metals, non steroidal anti-inflammatory drugs (NSAIDS) usage, and alcohol consumption.10-14  Available literature revealing 10 – 20% of cases of CKD being of unknown cause.18-20 Similarly exposure to petrochemicals has been implicated as a risk factor for CKD in some parts of Nigeria.21 The widespread use of agrochemicals among farming communities in Nigeria necessitate a coordinated research into the possibility of exposure to agrochemicals as an emerging risk factor for CKD.  This study will be conducted over 24 months. We expect that CKD risk factors hitherto unrecognized will now be a significant in preventive measures, thus widening the scope of preventive nephrology in a resource poor setting with a view to reducing economic burden.      

Learning or research objectives:
The specific aims are:
I.    To determine the level of exposure to agrochemicals by individuals in a rural farming community.
II.    To determine the prevalence of chronic kidney disease among such individuals who have been exposed and those unexposed to agrochemicals.
III.    To determine the relationship between level of exposure to agrochemicals and CKD. We hypothesized that exposure to agrochemicals will lead to increase prevalence of CKD among individuals exposed to agrochemical and this will explain some risk factors of CKD of unknown etiology.     

Additional Info

  • Year: 2016
  • Status: In progress
  • Partners: ISN only
  • Region: Africa
  • Country: Nigeria
  • Topics: CKD
Read 6949 times Last modified on Thursday, 16 March 2017 09:29

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