Follow Us:

social twitter box white 32 social facebook box blue 32social linkedin box blue 32 Youtube

Sandrine Damster

Sandrine Damster

Emanuel Effa
Name:
Emmanuel Edet Effa

Hospital/Affiliation: University of Calabar Teaching Hospital

Home Country: Nigeria

Host Country: South Africa

Year: started in 2017

Status of the program: IN PROGRESS

Title of the project:
Community based Chronic Kidney Disease Screening and educational intervention programme in Cross River State, Nigeria.

Topic:
CKD

Short description of the project or abstract:
Incident end stage renal disease (ESRD) worldwide is increasing at an annual rate of 8%. In sub Saharan Africa, this is related to the current double burden of infectious and non-communicable diseases especially hypertension and diabetes. Hospital based studies in Nigeria have reported chronic kidney disease (CKD) rates as ratios of hospital medical admissions put at between 1.6% and 10%. A few community based studies of CKD now exist. In spite of this, early stages are often unreported. Yet, this category of patients may benefit from therapy and/or kidney care education awareness strategies designed to prevent its onset, reverse kidney injury or delay its progression.
This will be a cross sectional study designed to provide much needed baseline information on the prevalence of and risk factors for chronic kidney disease in Cross River State with a view to informing healthcare policy at local level, to design appropriate intervention strategies and to provide data for future strategic planning. It is also designed to leverage the availability of mobile phone services in urban, semi-urban and rural communities to deliver behaviour changing information to people at risk. The at-risk people will include those with hypertension, diabetes, obesity as well as those engaged in potentially CKD causing habits such as tobacco intake, use of herbal remedies and habitual use of over the counter non-steroidal anti-inflammatory drugs. We will use the mass media (radio, TV, local newspaper) to publicize the study and rely on local helps for communicty mobilization. We will use trained field research assistants to collect data.
Information, Education and Communication (IEC) materials on prevention of kidney disease from the National Kidney Foundations website (https://www.kidney.org/prevention) will be contextually and linguistically adapted and used to educate eligible participants on preventive measures for CKD. In addition, these messages will be sent via text messages to enrolled participants at predetermined intervals. Subsequently, they will be contacted to ascertain adherence to delivered messages.

Learning or research objectives:
• To determine the prevalence of CKD among at-risk individuals in the Cross River State population.
• To determine the prevalence of risk factors of CKD among a sample of the Cross River State population
• To implement a CKD educational awareness programme using a blend of Information, Education and Communication (IEC) materials as well as follow up mobile short message service.
• To assess the level of adherence to lifestyle changes among those with or at risk of CKD             

J.Restrepo
Name:
Jaime Restrepo

Hospital/Affiliation: Fundacion Valle del Lili, Cali

Home Country: Colombia

Host Country: Colombia

Year: started in 2016

Status of the program: IN PROGRESS

 

Title of the project:
Incidence and Mortality of Acute Kidney Injury in Hospitalized Pediatric Patients in four Intensive Care Units in Colombian Southwest

Topic:
AKI

Short description of the project or abstract:

Learning or research objectives:

A.Arije
Name:
Ayodeji Arije

Hospital/Affiliation: University College Hospital/ College of Medicine, University of Ibadan

Home Country: Nigeria

Host Country: Nigeria

Year: started in 2016

Status of the program: IN PROGRESS

Title of the project:
Farming Practices as Risk Factors for CKD in Nigeria

Topic:
CKD

Short description of the project or abstract:
Chronic kidney disease (CKD) is a global health problem, and this was attested to by its recent inclusion on the list of non communicable diseases (NCDs) demanding urgent public attention by the World Health Organization (WHO).1 It occurs in 10% of the world population.2 However, an entity called CKD of unknown cause (CKDu) is increasingly being recognized.3-5 Previously the entity called Balkan nephropathy initially presented as kidney disease of unknown cause, until it was eventually identified and linked to some environmental factors prevalent in a localized region of the world.6-9 CKD of unknown cause has also been recently described as occurring in alarming proportions in certain deprived, poor, agricultural areas of the developing world. 3, 4, 10-14  Most of those affected do not have hypertension or diabetes mellitus. Implicated factors include the use of agrochemicals, dehydration, consumption of high sugar content fluids, exposure to heavy metals, non steroidal anti-inflammatory drugs (NSAIDS) usage, and alcohol consumption.10-14  Available literature revealing 10 – 20% of cases of CKD being of unknown cause.18-20 Similarly exposure to petrochemicals has been implicated as a risk factor for CKD in some parts of Nigeria.21 The widespread use of agrochemicals among farming communities in Nigeria necessitate a coordinated research into the possibility of exposure to agrochemicals as an emerging risk factor for CKD.  This study will be conducted over 24 months. We expect that CKD risk factors hitherto unrecognized will now be a significant in preventive measures, thus widening the scope of preventive nephrology in a resource poor setting with a view to reducing economic burden.      

Learning or research objectives:
The specific aims are:
I.    To determine the level of exposure to agrochemicals by individuals in a rural farming community.
II.    To determine the prevalence of chronic kidney disease among such individuals who have been exposed and those unexposed to agrochemicals.
III.    To determine the relationship between level of exposure to agrochemicals and CKD. We hypothesized that exposure to agrochemicals will lead to increase prevalence of CKD among individuals exposed to agrochemical and this will explain some risk factors of CKD of unknown etiology.     
     

 

Michael Alao
Name:
Michael Abel Alao

Hospital/Affiliation: Department of Paediatrics, University College Hospital Ibadan/Department of Paediatrics, Bowen University Hospital ogbomoso

Home Country: Nigeria

Host Country: Nigeria

Year: started in 2016

Status of the program: IN PROGRESS

Title of the project:
Community-based evaluation of renal dysfunction among children age 1-18 years using cystatin C in Ogbomoso Community, South-West
Nigeria.

Topic:
CKD, Pediatric Nephrology

Short description of the project or abstract:

Chronic Kidney Disease (CKD) has recently been designated a disease of public health importance. Its prevalence has risen significantly with end-stage renal disease (ESRD) rising 600% within a period of three decades as illustrated by the United States Renal Data System (USRDS). Children of African descent are 3 times more vulnerable to CKD than caucasians in the United States inferring a likely vulnerability of the Nigerian child.
However, limited data exist on GFR -based evaluation of renal function in sub-Saharan Africa in the community compared to hospital-based data which may not be representative of the general population.
This study seeks to determine the prevalence of CKD in the community using cystatin C, an early biomarker of  CKD, determine the severity and some associated risk factors.


Outcome:   
1: This study seeks to determine the community-based prevalence of CKD  using cystatin C-based eGFR in the paediatric population in Ogbomoso Community, South–West Nigeria.
2: Compare creatinine-based eGFR using Updated Schartz formula and cystatin C-based eGFR in Ogbomoso community
3: To identify some  factors associated with CKD in Ogbomoso  community

Rationale: Data available on CKD in paediatric are mainly hospital-based and may be non-representative of the true prevalence. Community–based study would capture the asymptomatic phase of  CKD well above hospital-based data. This may be an ideal starting point for evidence-based renal care.

Population and Study design: This is a longitudinal study involving 630 selected children among 126,922 subjects aged 1 to 18 years in Ogbomoso Community ,South-West Nigeria.

Duration: The study would last a period of eight months

Significance: There are limited prior paediatric eGFR-population-based studies in Nigeria.This intends to provide a cystatin C and creatinine –based eGFR of paediatric population in Nigeria.


Learning or research objectives:

• Determine the prevalence of CKD in the community using cystatin C.
• Determine eGFR of children aged 1 – 18 years.
• Determine the severity of CKD in the community using the eGFR.
• Compare creatinine based eGFR to cystatin C based eGFR.
• Risk factors for CKD in the community.


Department of Paediatrics, University College Hospital Ibadan/Department of Paediatrics, Bowen University Hospital ogbomoso

photo SidySeck

Name:Sidy Mohamed Seck

Hospital/Affiliation: University Gaston Berger of Saint-Louis/Faculty of Health Sciences

Home Country: Senegal

Host Country: Dakar

Year: started in 2016

Status of the program: IN PROGRESS

 

Title of the project:
Acute kidney injury (AKI) epidemiology and unmet needs of care in Senegalese pregnant women

Topic:
AKI

Short description of the project or abstract:

Learning or research objectives:

Name: ErEranga Wijewickramaanga Wijewickrama

Hospital/Affiliation: Faculty of Medicine, University of Colombo

Home Country: Sri Lanka

Host Country: Sri Lanka

Year: started in 2017

Status of the program: IN PROGRESS


Title of the project:
Prevalence of chronic kidney disease and its association with exposure to heavy metals and other environmental toxins in a rural population in Sri Lanka

Topic:
CKD

Short description of the project or abstract:
Chronic kidney disease is on the rise globally. The main contributory factors are the increased incidence of diabetes and hypertension. The situation is somewhat different in certain parts of Sri Lanka where the disease is reaching epidemic proportions in the absence of these traditional risk factors. This, CKD of uncertain aetiology, is predominantly seen in the North Central Province and involve the farming community belonging to the low socio-economic class. The absence of typical risk factors of CKD, restriction of the disease to certain geographical locations, its prevalence among farming communities and the histopathological findings suggest the involvement of a single or multiple environmental nephrotoxins in the aetiology of CKDu. Hardness of drinking water, fluoride, agrochemicals, heavy metals such as arsenic and cadmium are some of the postulated toxins however none have been proven to be associated with the disease.
Increasing numbers of CKD cases are being reported from certain areas of Moneragala district, which lie outside the general confines of CKDu endemic area in Sri Lanka. The actual prevalence of the disease and associated risk factors are not known. The proposed study is intended to identify the true prevalence of CKD in this rural high-risk region and to determine its association with the environmental nephrotoxins including heavy metals such as arsenic, cadmium and lead.
The study will be carried out in identified high risk areas of the Moneragala district and the selected individuals will be screened with serum creatinine, urine for albumin:creatinine ratio and β2 microglobulin levels. A detailed questionnaire will be used to identify exposures to possible environmental toxins. Levels of urinary arsenic, cadmium and lead will be measured in all in order to identify an association with CKD.
The study will not only have a research value but will have implications on screening, instituting preventative measures and treatment strategies for the individuals living in the area. The information obtained will also shed light on the aetiology and pathogenesis of CKD of unknown aetiology elsewhere in the world including Central America where the affected share certain work exposures with the inhabitants of this rural area in Moneragala.

Learning or research objectives:
In a rural population of Sri Lanka:
1.1:    To describe the prevalence of CKD
1.2:    To describe the prevalence of CKDu
1.3:    To describe the prevalence of β2 microglobulinuria
1.4:    To assess the role of environmental risk factors including heavy metals in the development of CKD and β2 microglobulinuria

 

Page 2 of 2

WCN 2020

website new logo

Global Operations Center

Avenue des Arts 1-2
1210 Brussels, Belgium
Tel: +32 2 808 04 20
Fax: +32 2 808 4454
Email contact

               

Americas Operations Center

340 North Avenue 3rd Floor
Cranford, NJ 07016-2496, United States
Tel: +1 567 248 9703
Fax: +1 908 272 7101
Email contact