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Monday, 06 March 2017 11:44

Clinical Research: Community-based evaluation of renal dysfunction among children age 1-18 years using cystatin C in Ogbomoso Community, South-West Nigeria.

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Michael Alao
Name:
Michael Abel Alao

Hospital/Affiliation: Department of Paediatrics, University College Hospital Ibadan/Department of Paediatrics, Bowen University Hospital ogbomoso

Home Country: Nigeria

Host Country: Nigeria

Year: started in 2016

Status of the program: IN PROGRESS

Title of the project:
Community-based evaluation of renal dysfunction among children age 1-18 years using cystatin C in Ogbomoso Community, South-West
Nigeria.

Topic:
CKD, Pediatric Nephrology

Short description of the project or abstract:

Chronic Kidney Disease (CKD) has recently been designated a disease of public health importance. Its prevalence has risen significantly with end-stage renal disease (ESRD) rising 600% within a period of three decades as illustrated by the United States Renal Data System (USRDS). Children of African descent are 3 times more vulnerable to CKD than caucasians in the United States inferring a likely vulnerability of the Nigerian child.
However, limited data exist on GFR -based evaluation of renal function in sub-Saharan Africa in the community compared to hospital-based data which may not be representative of the general population.
This study seeks to determine the prevalence of CKD in the community using cystatin C, an early biomarker of  CKD, determine the severity and some associated risk factors.


Outcome:   
1: This study seeks to determine the community-based prevalence of CKD  using cystatin C-based eGFR in the paediatric population in Ogbomoso Community, South–West Nigeria.
2: Compare creatinine-based eGFR using Updated Schartz formula and cystatin C-based eGFR in Ogbomoso community
3: To identify some  factors associated with CKD in Ogbomoso  community

Rationale: Data available on CKD in paediatric are mainly hospital-based and may be non-representative of the true prevalence. Community–based study would capture the asymptomatic phase of  CKD well above hospital-based data. This may be an ideal starting point for evidence-based renal care.

Population and Study design: This is a longitudinal study involving 630 selected children among 126,922 subjects aged 1 to 18 years in Ogbomoso Community ,South-West Nigeria.

Duration: The study would last a period of eight months

Significance: There are limited prior paediatric eGFR-population-based studies in Nigeria.This intends to provide a cystatin C and creatinine –based eGFR of paediatric population in Nigeria.


Learning or research objectives:

• Determine the prevalence of CKD in the community using cystatin C.
• Determine eGFR of children aged 1 – 18 years.
• Determine the severity of CKD in the community using the eGFR.
• Compare creatinine based eGFR to cystatin C based eGFR.
• Risk factors for CKD in the community.


Department of Paediatrics, University College Hospital Ibadan/Department of Paediatrics, Bowen University Hospital ogbomoso

Additional Info

  • Year: 2016
  • Status: In progress
  • Partners: ISN only
  • Region: Africa
  • Country: Nigeria
  • Topics: Paediatric nephrology
Read 735 times Last modified on Tuesday, 07 March 2017 10:02

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