Day 1

Day 1 – July 1, 2021

Welcome

11:00 Welcome from the ISN
11:10 Welcome from the 2021 ISN Frontiers Meeting Chairs Giuseppe Remuzzi Italy
Marina Noris Italy
Raja Ramachandran India
Opening
plenary lecture
11:15 Rare renal diseases of complement dysregulation: open a window on the future of medicine Giuseppe Remuzzi Italy
Immune complex associated membranoproliferative glomerulonephritis and C3 glomerulopathy

Session 1:

What have we learnt from animal models?

12:00 The complement system and the kidney in humans and rodents Richard Quigg United States
12:15 Mouse models of C3G: role of C3 and C5 activation products Matthew Pickering United Kingdom
12:30 Oral presentation from abstract selection
12:40 Discussion
Lunch break 13:00 Lunch and poster viewing

Session 2:

Advances in pathophysiology

14:00 Genetic basis: CFHR hybrids Santiago Rodriguez De Cordoba Spain
14:15 Genetic basis: the role of rare and common complement gene variants Rossella Piras Italy
14:30 Nephritic factors: a heterogenous family of complement-activating autoantibodies Sophie Chauvet France
14:45 Anti-complement autoantibodies in C3G/IC-MPGN and in other complement-mediated glomerulopathies Veronique Fremeaux-Bacchi France
15:00 Oral presentation from abstract selection
15:10 Discussion
Coffee break 15:30 Coffee break and poster viewing

Session 3:

Clinical: unanswered questions

16:00 Recent history of C3G/IC-MPGN throughout the lens of a clinician Gerald Appel United States
16:15 The variable expression of C3G/IC-MPGN: complement, post-infectious, paraproteins Marina Vivarelli Italy
16:30 Maths helps clinicians with making a diagnosis and predicting outcomes Marina Noris Italy
16:45 Oral presentation from abstract selection
16:55 Discussion
Keynote lecture 17:15 C3G/IC-MPGN in 2021 Richard Smith United States