Weize Chen
Young Nephrologists Award: Best Basic Science Abstract
Dr Weize Chen obtained his Bachelor’s degree in clinical medicine at Shanghai Medical College, Fudan University, in 2020, and is now a PhD candidate in the Department of Nephrology, Zhongshan Hospital, Fudan University. His research focuses on the function of cellular prion protein (Prpc) in progression of kidney diseases. Cellular prion protein is a cell-surface copper-binding glycoprotein that is a highly conserved soluble secretory protein mainly presented in the extracellular matrix and functions as a “molecular messenger” between cells. Dr. Chen clarified after kidney injury, rapidly activated fibroblasts secrete Prpc, which acts on the TSPAN7 protein in renal tubular epithelial cells, mediates the formation of migrasome, promotes the repair of renal tubular epithelial cells, and reduces AKI. His study elucidated the potential new mechanism of AKI.
Abstract: Cellular prion protein attenuates renal fibrosis by interacting with TSPAN7 to induce formation of migrasome
The WCN Young Nephrologists session, ‘AKI and Critical Care Nephrology in Latin America – By the ISN Young Nephrologists Committee,’ is Sunday, April 14, 2024, from 9-10:30 am Argentina Time in Hall C3.