Events - Industry e-symposium: Genetic and Clinical Implications in aHUS Management

This webinar will explore the critical role of genetics in the prognosis and management of atypical Hemolytic Uremic Syndrome (aHUS), with a focus on practical clinical applications. Key topics include using genetic insights for risk stratification, determining prognosis, and guiding treatment duration and goals. Designed for a global audience, the session will address how clinicians can integrate genetic data into actionable strategies to improve patient outcomes across diverse healthcare settings.

Learning objectives: 

• Role of Genetics: Understand the critical importance of genetic insights in managing atypical Hemolytic Uremic Syndrome (aHUS) and how it is not necessary for diagnosis but informative for prognosis.
• Risk Stratification: Learn how to use genetic data to assess patient risk levels and tailor clinical approaches accordingly.
• Prognosis Determination: Gain knowledge on leveraging genetic information to predict disease progression and outcomes for better patient planning.
• Practical Integration: Explore actionable strategies to incorporate genetic data into everyday clinical practice across diverse healthcare settings.

Further reading:

• Anuja Java aHUS Diagnosis, Management and Discontinuation of Treatment 2024 ASH education program DOI 10.1182/hematology.2024000543
• Ren Z, et al., (2021) Clinicopathologic Implications of Complement Genetic Variants in Kidney Transplantation. Front. Med. 8:775280. doi: 10.3389/fmed.2021.775280
• Le Quintrec et al 2013 Complement Genes Strongly Predict Recurrence and Graft Outcome in Adult Renal Transplant Recipients with Atypical Hemolytic and Uremic Syndrome American Journal of Transplantation 2013; 13: 663–675 doi: 10.1111/ajt.12077
• Klomjit et al., Gene−Environment Interaction: Lessons From Complement-Mediated Kidney Disease Seminars in Nephrology, Vol45, No4, July 2025,151657
• Noris M, Bresin E, Mele C, et al. Genetic Atypical Hemolytic-Uremic Syndrome. 2007 Nov 16 [Updated 2021 Sep 23]. In: Adam MP, Feldman J, Mirzaa GM, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2025. Bookshelf URL: https://www.ncbi.nlm.nih.gov/books/
• Franz Shaefer et al., Clinical and genetic predictors of atypical hemolytic uremic syndrome phenotype and outcome Kidney International (2018) 94, 408–418; https://doi.org/10.1016/ j.kint.2018.02.029