Jan 12 2023
January 12, 2023

Grand Rounds in Pediatric Nephrology – an ISN-IPNA Sister Centers initiative: Renal amyloidosis presenting as glucocorticoid resistant nephrotic syndrome

  • 2:00 PM

Amyloidosis is a rare multi-system disease. In children, amyloid A (AA) amyloidosis (previously known as reactive or secondary amyloidosis) may occur due to chronic inflammation. Pediatric AA amyloidosis mainly  involves the kidneys and presents with proteinuria, hematuria, hypertension and nephrotic syndrome. Therapy for AA amyloidosis is targeted towards control of the underlying inflammatory disease and suppression of serum amyloid protein production. 

In this webinar, we will present a case of renal amyloidosis, successfully treated with IL-6 antibody.  

Learning objectives:

  • Differential diagnosis of a child presenting with steroid resistant nephrotic syndrome
  • Histological findings in a case with renal amyloidosis and pathogenesis
  • Mechanism and role of IL-6 antibody in the treatment of renal amyloidosis

Further reading:


Rukshana Shroff (UK)


Martin Bitzan (United Arab States)

Girish Chandra Bhatt (India)

Deepali Malviya (India)