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ISN TrialWatch | Special Edition

Rituximab for Relapse Prevention in Adult Frequently Relapsing and Steroid-Dependent Nephrotic Syndrome
Rituximab for Relapsing Nephrotic Syndrome in Adults. A Randomized Clinical Trial. This multicenter, double-blind, randomized, placebo-controlled trial evaluated the efficacy and safety of rituximab for preventing relapse in adults with frequently relapsing nephrotic syndrome (FRNS) or steroid-dependent nephrotic syndrome (SDNS).

ISN TrialWatch | Oct – Nov – Dec 2025

IVIG Modulates Fibrosis and Stabilizes Chronic Active AMR Progression
A randomized controlled trial of intravenous immunoglobulin vs standard of care for the treatment of chronic active antibody-mediated rejection in kidney transplant recipients. Chronic active antibody-mediated rejection (AMR) is the primary cause of kidney allograft loss beyond 5 years and currently has no evidence-based long-term therapy.
Trial of the month:

ISN TrialWatch | Feb – Mar 2025

Remote monitoring for automated PD improves cardiovascular outcomes
A device integrated into the automated PD cycler facilitates remote monitoring (RM) of automated peritoneal dialysis (APD), enabling medical staff to track essential PD parameters. This multicentre, clusterrandomized, open-label trial included 403 patients in the RM-APD group and 398 patients in the conventional treatment group.
Trial of the month:

ISN TrialWatch | Dec – Jan 2025

Enhancing quality of life: role of targeted exercises for children on hemodialysis
In this single-center study, 68 children on maintenance hemodialysis were randomized to receive either a 40-minute thrice weekly exercise program during hemodialysis for 2 months or routine care. A trained physical therapy researcher taught the exercises, including lower limb stretches (10 repetitions per muscle) during the first 20 minutes of the second hour of dialysis,
Trial of the month: