Complement-mediated kidney diseases (CMKDs), although less well-known and considered rare, are an important and complex area of kidney health that needs to be better recognized so that optimal care may be provided.
There are over 40 activating and inhibiting proteins in three separate pathways of complement system that finally converge into a common terminal pathway. The kidney is particularly susceptible to damage by complement. Activation of the complement system is tightly regulated by a series of soluble and membrane bound proteins. Failure of these checking mechanisms is one of the major causes and/or drivers of CMKDs.
Raising awareness of these diseases and developing educational and implementation tools supports clinicians in building their understanding of CMKDs, and in their clinical practice.
Discover the toolkit below, and stay tuned as more tools and resources are added periodically.
Disclaimer text: This toolkit is intended to facilitate decision making of health professionals in their daily practice. However, final decisions concerning an individual patient must be made by the responsible health professional(s) in consultation with the patient and caregiver as appropriate. The ISN declines any responsibilities for any damage caused by the use that may be made of the information provided in this toolkit.