Acute Kidney Injury

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ISN TrialWatch | Aug – Sept 2025

Spironolactone did not ACHIEVE cardiovascular risk reduction in dialysis
Spironolactone versus placebo in patients undergoing maintenance dialysis (ACHIEVE): an international,The ACHIEVE trial randomized 2,538 hemodialysis and peritoneal dialysis patients who tolerated a 4-week spironolactone run-in (25 mg daily) to spironolactone versus placebo, with a median follow-up of 1.8 years. Approximately 63% of participants were male, 43% had diabetic kidney disease, and the mean age was 62 years.
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ISN TrialWatch | June – July 2025

Stronger Together: Finerenone & Empagliflozin Boost Kidney Outcomes in Diabetes
Finerenone with Empagliflozin in Chronic Kidney Disease and Type 2 Diabetes The CONFIDENCE trial was a double-blind, randomized study enrolling 800 participants with chronic kidney disease (CKD) (eGFR 30–90 ml/min/1.73 m²), albuminuria (urinary albumin-to-creatinine ratio [UACR] 100– 5000 mg/g), and type 2 diabetes, all of whom were receiving renin–angiotensin system inhibitors. Participants were randomly assigned in a 1:1:1 ratio to...
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