Glomerular diseases

ISN TrialWatch

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ISN TrialWatch | Oct – Nov – Dec 2025

IVIG Modulates Fibrosis and Stabilizes Chronic Active AMR Progression
A randomized controlled trial of intravenous immunoglobulin vs standard of care for the treatment of chronic active antibody-mediated rejection in kidney transplant recipients. Chronic active antibody-mediated rejection (AMR) is the primary cause of kidney allograft loss beyond 5 years and currently has no evidence-based long-term therapy.
Trial of the month:

ISN TrialWatch | Apr – May 2025

DAPA-Tolvaptan: First trial of SGLT2 inhibition in ADPKD with background tolvaptan therapy
In this open-label, crossover trial, 27 autosomal dominant polycystic kidney disease (ADPKD) participants on stable high-dose tolvaptan (>60mg/day, >3 months, with eGFR >25 ml/min/1.73 m2) were randomized to receive dapagliflozin 10mg daily or usual care for 6-months, then crossed to the alternate arm for another 6 months, without a washout period.
Trial of the month: