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Latest ISN Journal Summaries

Kidney International® 

Mayo Clinic Consensus Report on Membranous Nephropathy: Proposal for a Novel Classification 

This report proposes a two-step classification of membranous nephropathy (MN). Step one is identifying the target antigen based on a multistep algorithm. The second step is the search for a potential underlying disease or associated condition.

The meeting consensus favored using an antigen-based classification of MN because this method supports more accurate and specific diagnosis, with significant implications for patient management and targeted treatment.

Post-hoc Analysis of the SONAR Trial Indicates That the Endothelin Receptor Antagonist Atrasentan is Associated With Less Pain in Patients With Type 2 Diabetes and Chronic Kidney Disease 

This post hoc analysis of the SONAR trial assessed the association between the endothelin receptor antagonist atrasentan and pain and the prescription of analgesics.

Atrasentan was associated with reduced pain-related events and pain-related use of analgesics in carefully selected patients with type 2 diabetes and chronic kidney disease.


Kidney International Reports® 

Evaluating Progression Risk in Patients With Immunoglobulin A Nephropathy

This review addresses the challenge of predicting kidney function decline in IgAN patients.

The authors discuss existing markers and describe a route to improving prognosis using robust, clinically practical markers to inform patient care.

The authors stress the need for focused biomarker research incorporating risk stratification to help delay or prevent progression to dialysis and increase remission rates in IgAN patients.

Sex/Gender-based Disparities in Early Transplant Access by Attributed Cause of Kidney Disease – Evidence From a Multi-regional Cohort in the Southeast United States

This study examined sex/gender disparities across the continuum of transplant care by attributed cause of kidney failure. The authors found that women with kidney failure and diabetes or hypertension were less likely to be referred, evaluated, and waitlisted for kidney transplantation in the Southeast United States.

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