Research

Latest ISN Journal Editorial Selections

Kidney International®  NAVKIDS2: A Lesson in Matching Outcomes Measures to Interventions   The Randomized Controlled Trial (NAVKIDS2) of a Patient Navigator Program Created for Children With Chronic Kidney Disease   These two studies evaluate a patient navigation program for children from disadvantaged backgrounds with chronic kidney disease (CKD), aiming to improve access to evidence-based care.   While the patient navigation...

A New Intervention for TARGETing Resistant Hypertension

Effect of Alcohol-Mediated Renal Denervation on Blood Pressure in the Presence of Antihypertensive Medications: Primary Results From the TARGET BP I Randomized Clinical Trial Kandzari et al, Circulation, 2024 Jun 11;149(24):1875-1884 ISN-ACT Global Trials Focus coordinator Megan Borkum summarizes the design and outcomes of one of the latest ISN-ACT Global Trials Focus (GTF) selections. Summary: The TARGET...

ISN-GKHA Data Highlights Progress and Challenges in Global Kidney Care Delivery: BMJ Publication  

The BMJ has published the paper, "Progress of Nations in the Organisation of, and Structures for, Kidney Care Delivery Between 2019 and 2023: Cross-Sectional Survey in 148 Countries" by Okpechi et al.   Using data from the ISN Global Kidney Health Atlas (GKHA) 2019 and 2023 reports, the study analyzed changes in the availability of kidney...

Depression Management With Sertraline in Maintenance Hemodialysis Patients

ISN-ACT Global Trials Focus Subgroup member Marimar Contreras Nieves summarizes the design and outcomes of one of the latest ISN-ACT Global Trials Focus (GTF) selections. The Efficacy and Safety of Sertraline in Maintenance Hemodialysis Patients With Depression: A Randomized Controlled Study Zhang et al., J Affect Disord, 2024 May, 1:353:60-66 Summary This study evaluated the efficacy and safety of...

ISN’s Global Kidney Health Atlas 2023 Data Highlights Kidney Care Inequalities in New Supplement Release

The Nephrology Dialysis Transplantation (NDT) Supplement "Current Status of Kidney Care Services Across Countries: A Report from the International Society of Nephrology Global Kidney Health Atlas (ISN-GKHA)" presents results from the third edition of the ISN-Global Kidney Health Atlas in a curated selection of articles relevant to public policy on kidney care. The articles highlight significant...

Investigating the Economic Burden and Cost-effectiveness Evidence Base for Rare Kidney Diseases

Rare kidney diseases (RKD) place a substantial economic burden on patients and health systems, the extent of which is unknown and may be systematically underestimated by health economic techniques. The “Scoping Review of Economic Analyses of Rare Kidney Diseases,” written in collaboration with The George Institute for Global Health, examines the existing evidence base toward...

Explore the Latest ISN Global Trials Focus Selections Featuring a “Trial of the Month” on the Effects of Semaglutide on CKD in People With Type 2 Diabetes

ISN-ACT Global Trials Focus editorial team member Michele Provenzano summarizes the design and outcomes of the latest "Trial of the Month" featured in ISN-ACT Global Trials Focus. The "Trial of the Month" is available in several languages, now including German. Read all global trial selections from the ISN-ACT initiative here. In addition, in the ISN 'Guide for Everyone' series,...

Should You Proceed With Surgery or Tablets in Peritoneal Dialysis Patients With Advanced Secondary Hyperparathyroidism?

ISN-ACT Global Trials Focus contributor Ahad Qayyum summarizes the design and outcomes of one of the ISN-ACT Global Trials Focus's latest trial selections. The "Trial of the Month" is available in several languages, now including German. Read all global trial selections from the ISN-ACT initiative here. In addition, in the ISN 'Guide for Everyone' series, selected clinical trials...

Top 5 Reasons to Submit an Abstract to WCN’25

It's abstract submission season! Submitting an abstract to WCN'25 is an excellent way to showcase your research and advance your career. Find out more and submit your abstract here Here are the top 5 reasons to get motivated and submit your abstract today – think abstract, think NEPHRO! NEtworking: Cultivate lasting professional relationships Prominence: Showcase your research on...

Two New ISN Global Kidney Care Podcasts on Peritoneal Dialysis Practices and Advancing Expertise Through the Educational Ambassadors Program – Catch Up Now! 

The Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS) is designed to advance the understanding of optimal practices for PD patients worldwide. Hear from DOPPS Program Scientific Director Roberto Pecoits-Filho in conversation with ISPD President Edwina Brown and PDOPPS International Steering Committee members Jeffrey Perl and Jenny Shen. Listen here Recorded live at WCN '24 in...

Hear From Global Experts on Equitable Access to Innovative Therapies

Aligning with the 2024 World Kidney Day theme, "Advancing equitable access to care and optimal medication practice," Nature Reviews Nephrology has published an editorial on innovative therapies for diabetic kidney disease (DKD). Five global experts* from different world regions, including authors of the 2024 World Kidney Day scientific editorial, discuss barriers that must be...

Metabolic Acidosis in CKD – to Treat or Not to Treat? Still an Unresolved Mystery

ISN-ACT Global Trials Focus contributor Sara Ksiazek summarizes the design and outcomes of one of the ISN-ACT Global Trials Focus's latest trial selections. The "Trial of the Month" is available in several languages, now including German. Read all global trial selections from the ISN-ACT initiative here. In addition, in the ISN 'Guide for Everyone' series, selected clinical trials...

A Simple Method to Reduce Hypotension During Hemodialysis: Ascending-Descending Ultrafiltration With Linear Sodium Profiling

ISN-ACT Global Trials Focus editorial team member Dominik Tuechler summarizes the design and outcomes of one of the ISN-ACT Global Trials Focus's latest trial selections. The "Trial of the Month" is available in several languages, now including German. Read all global trial selections from the ISN-ACT initiative here. In addition, in the ISN 'Guide for Everyone' series, selected...

Explore the Latest ISN Global Trials Focus Selection, Featuring a “Trial of the Month” on the Phase 2 Trial of Cemdisiran in Adult Patients with IgA Nephropathy

ISN-ACT Global Trials Focus editorial team member Megan Borkum summarizes the design and outcomes of the latest ISN-ACT Global Trials Focus "Trial of the Month." The "Trial of the Month" is available in several languages, now including German. Read all global trial selections from the ISN-ACT initiative here. In addition, in the ISN 'Guide for Everyone' series, selected clinical trials...

New Section on Risk Matrix Available Now in the ISN-ACT Toolkit

The ISN-ACT Toolkit has been extended to include a chapter on risk management – a fundamental pillar in the planning and executing of clinical trials that helps categorize risks based on their likelihood of occurrence and potential impact on the study. This new section was contributed by ISN-Advancing Clinical Trials Committee member Dr. Paula Andrea...

Advancing #Green Nephrology: Strategies and Insights From ISN Emerging Leaders Cohorts Published in Scientific Journals 

The paper "Climate Change, Kidney Health, and Environmentally Sustainable Kidney Care" by ISN Emerging Leaders Program (ELP) cohort 2 members has been published in the Journal of the American Society of Nephrology (JASN).   Read the paper here  The cohort conducted a cross-sectional survey to:   Understand knowledge, attitudes, and practices among healthcare professionals concerning the link between climate...

Avacopan and Rituximab – A Promising Combination for Patients With ANCA-Associated Vasculitis

Read all global trial selections from the ISN-ACT initiative here. The “trial of the month” is available in several languages. In addition, selected clinical trials are demystified for the layperson. ISN-ACT Global Trials Focus Subgroup member Nikolay Bulanov summarizes the design and outcomes of one of the ISN-ACT Global Trials Focus’s latest trial selections. Efficacy and safety of...

Latest ISN Journal Editorial Selections 

Kidney International®  Time for Action: Recognizing Chronic Kidney Disease as a Major Noncommunicable Disease Driver of Premature Mortality  This editorial outlines the significant global burden of chronic kidney disease and highlights the timeliness of a global consensus statement from the ISN, the European Renal Association, the American Society of Nephrology, regional societies, and experts, recently published...

American Journal of Kidney Diseases Publishes Paper From 2023 ISN-Global Kidney Health Atlas Data

The paper "Organization and Structures for Detection and Monitoring of CKD Across World Countries and Regions: Observational Data From a Global Survey" has been published in the American Journal of Kidney Diseases. Read the paper by Tungsanga et al. here The ISN-Global Kidney Health Atlas (ISN-GKHA) is a worldwide survey assessing current kidney care capacity. Early detection...

Sleep-HD Trial Results: The Quest Continues for an Effective Therapy For Insomnia in Hemodialysis Patients

Read all global trial selections from the ISN-ACT initiative here. The “trial of the month” is available in several languages. In addition, selected clinical trials are demystified for the layperson. ISN-ACT Global Trials Focus editorial team member Megan Borkum summarizes the design and outcomes of one of the ISN-ACT Global Trials Focus’s latest trial selections. Effectiveness...