Research

Explore Global Variance in Kidney Care Capacity: Papers Summarizing ISN-GKHA Regional Data Published in Kidney International® Supplements

The 2023 ISN Global Kidney Health Atlas (GKHA) sheds light on the current global capacity to deliver kidney care. Read the Kidney International® Supplements papers here A collection of papers published in Kidney International® Supplements focuses on each of the ten ISN regions, presenting a comprehensive overview of kidney care services by world region. They highlight...

Sharing Expertise to Establish Renal Registries Worldwide: Read the ISN SharE-RR Publication Introducing Its Toolkit

The ISN Sharing Expertise to Support the Set-up of Renal Registries (ISN SharE-RR) initiative develops resources to help establish or develop renal registries in emerging countries. Find more information on SharE-RR here The SharE-RR Advisory Group has created a step-by-step toolkit to guide nephrologists, public health officials, and others to establish and maintain successful, sustainable renal...

Protecting IgA Nephropathy Patients: Sparsentan Reduces Proteinuria and Preserves Kidney Function Through to Two Years

ISN-ACT Global Trials Focus editorial team member Neeru Agarwal summarizes the design and outcomes of one of the ISN-ACT Global Trials Focus's latest trial selections. Read all global trial selections from the ISN-ACT initiative here. The "trial of the month" is available in several languages. In addition, selected clinical trials are demystified for the layperson. Efficacy and safety...

A Ray of Light for People Living With Chronic Kidney Disease: A Promising Digital Physical Activity Intervention

ISN-ACT Global Trials Focus editorial team member Megan Borkum summarizes the design and outcomes of one of the ISN-ACT Global Trials Focus's latest trial selections. Read all global trial selections from the ISN-ACT initiative here. The "trial of the month" is available in several languages. In addition, selected clinical trials are demystified for the layperson. Evaluating the effect...

Sparsentan Decreased Proteinuria, but Failed to Slow eGFR Decline in FSGS: Data From the DUPLEX Trial – New Selection of Global Trials Out Now!

ISN-ACT Global Trials Focus Subgroup member Anastasiia Zykova summarizes the design and outcomes of the team's latest "Trial of the Month." Stay updated on the latest research and developments in kidney care: Access the new selection of global trials from the ISN-ACT initiative here. The "Trial of the Month" is available in several languages. Sparsentan Versus Irbesartan...

The Lancet Global Health Publishes ISN Paper on Global Insights From the 2023 ISN-Global Kidney Health Atlas

The paper "An Update on the Global Disparities in Kidney Disease Burden and Care Across World Countries and Regions" has been published in The Lancet Global Health. Read the paper here. In the same edition, The Lancet Global Health published an editorial on the paper: "The Major Global Burden of Chronic Kidney Disease." Read the editorial...

Expanding Skills and Knowledge in Key Areas of Kidney Care: Access Three New ISN Implementation Toolkits

As part of the ISN-WHO 2021-2023 collaboration plan, the ISN is pleased to announce the release of three new implementation toolkits. The ISN thanks all experts involved for their outstanding contributions. Acute Kidney Injury (AKI) Toolkit The toolkit facilitates AKI detection, management, and prevention, integrating key strategies highlighted in the ISN 0by25 initiative. Access here The toolkit was developed...

“An Essential Advocacy Tool That Young Nephrologists Should Wholeheartedly Endorse”: Yannick Nlandu on the ISN-Global Kidney Health Atlas

By Yannick Nlandu (DR Congo), YNC member and  ISN-GKHA Named Fellow   Most nephrologists dream of solving kidney health problems in their communities, typically requiring a more generalist approach to public health. However, nephrology programs in general, and in low-resource countries in particular, do not integrate this broad vision of kidney health. Nephrologists, therefore, need to...

Demystifying Global Kidney Trials: Providing Clear Explanations for All With a New ISN Patient-Focused Initiative

Discover the "ISN Global Kidney Trials Insights: A Guide for Everyone," a new ISN initiative for people living with kidney diseases and others interested in kidney-related clinical trials. The project intends to foster meaningful communication between patients and kidney care practitioners and increase patient participation in clinical trials. Read the first study in the guide comparing...

What is the ISN Doing About the Challenge of Chronic Kidney Disease of Unknown Origin?

Despite ongoing efforts, chronic kidney disease of unknown origin (CKDu) remains a significant, persistent challenge in several world regions. As part of its commitment to advancing equitable kidney care worldwide, the ISN launched the ISN i3C (CKDu) Network at WCN 2017 to facilitate global CKDu-related collaboration and data collection and dissemination. Explore the details of...

“Integral in Enabling Me to Start My Research Career”: ISN Clinical Research Program Facilitates Groundbreaking Study on Dialysis in Zimbabwe

Rumbidzai Dahwa received an ISN Clinical Research Program (CRP) grant for the research project "Prevalence of Chronic Kidney Disease in Zimbabwe" in 2017. Find out more about the CRP and how to apply here. The study, completed in 2020, was the first to provide comprehensive data on the nature and prevalence of dialysis in Zimbabwe and...

Tackling the CKDu Puzzle: Read the ISN i3C Working Group’s Position Statement on Kidney Biopsies

Despite ongoing efforts, chronic kidney disease of unknown origin (CKDu) remains a significant, persistent problem in several world regions. The ISN i3C (CKDu) Working Group has written a comprehensive position statement offering vital guidance and recommendations for kidney biopsies in individuals suspected of CKDu. Read "Kidney Biopsies Among Persons Living in Hotspots of CKDu: A...

The ISN Applauds Ten New ISN-Named Fellows

Please join us in congratulating: Michele Provenzano for ISN-ACT (clinical trials) Anna Strasma for ISN i3C CKDu (chronic kidney disease of unknown origin) Winston Fung, Anukul Ghimire, Georgina Irish, Sabine Karam, Yannick Nlandu, Anna Petrova, Samveg Shah and Elliot Tannor for ISN-GKHA (Global Kidney Health Atlas) Get to know our ISN-Named Fellows here. These early-career ISN members were approved as...

ENVISION-ing a New Way Forward in IgA Nephropathy A Phase 2 Trial of Sibeprenlimab 

Daniel O’Hara, ISN-ACT Global Trials Focus coordinator, summarizes the design and outcomes of the latest "Trial of the Month." Explore all the global trial selections for November and December here. The "Trial of the Month" is available in several languages. A Phase 2 Trial of Sibeprenlimab in Patients With IgA Nephropathy Mathur et al., N Engl J Med...

Efficacy of Gravity-driven Continuous Flow Peritoneal Dialysis in Children

Rupesh Raina, ISN-ACT Global Trials Focus Subgroup member, summarizes the design and outcomes of one of the team's latest trial selections. Read all the latest global trial selections from the ISN-ACT initiative here. The "Trial of the month" is available in several languages. Gravity-assisted Continuous Flow Peritoneal Dialysis Technique Use in Acute Kidney Injury in Children: A...

Latest ISN Journal Editorial Selections

Precision medicine framework for optimizing CKD treatment Kidney International® Trends and Perspectives for Improving Quality of Chronic Kidney Disease Care: Conclusions From a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference  The conference discussed improving chronic kidney disease (CKD) diagnosis, care safety, and patient well-being, identifying current tools, barriers, and research needs in CKD management. Discussions acknowledged that...

Structured Delivery of Cognitive Behavioural Therapy and Targeted Symptom Management Can Improve Fatigue, Pain and Depression Among Those on Dialysis

Daniel O’Hara, the ISN-ACT Global Trials Focus coordinator, summarizes the design and outcomes of one of the team’s latest trial selections. Read all the latest global trial selections from the ISN-ACT initiative here. The “trial of the month” is available in several languages. Effects of Technology-assisted Stepped Collaborative Care Intervention to Improve Symptoms in Patients Undergoing Hemodialysis:...

Letermovir Non-inferior to Valganciclovir for CMV Prophylaxis, With Lower Leukopenia Rates

ISN-ACT Global Trials Focus Subgroup member Maria Chiara Pelle summarizes the design and outcomes of one of the ISN-ACT Global Trials Focus’ latest trial selections. Read all the latest global trial selections from the ISN-ACT initiative here. The “trial of the month” is available in several languages. Letermovir vs Valganciclovir for Prophylaxis of Cytomegalovirus in High-risk Kidney Transplant...