From unusual presentations and diagnostic dilemmas to novel treatment approaches, the first in press case reports featured in Kidney International Case Reports™ (KICR) highlight clinically relevant lessons from real-world kidney care across diverse global settings. Explore the first edition Among the early reports are cases that underline how rapidly evolving therapies are reshaping practice. Al Haddad...
Kidney International® A secondary analysis of the TESTING trial predicted individual patient response to corticosteroid treatment in IgA nephropathy This study addressed how to better target corticosteroid treatment in IgA nephropathy, (IgAN) where benefits must be weighed against important side effects. Using a secondary analysis of the TESTING trial, the authors developed a model to predict each patient’s likely response to...
Ten years ago, Kidney International Reports® (KIR) launched with a clear mission: to expand access to high-quality kidney research and ensure that important discoveries reach clinicians, researchers, and health systems worldwide. Over the past decade, the journal has published studies that have shaped care and policy, fostered opportunities for early-career researchers to contribute and collaborate, and elevated voices...
NephJC has extended the conversation around WCN’26 late-breaking trials with expert commentary on selected studies presented in Yokohama, including the ASSIST trial, 24-month data from APPLAUSE-IGAN, and new analyses from the CONFIDENCE trial. Read the commentaries A video interview recorded onsite at WCN’26 in Yokohama features NephJC Founding Editor-in-Chief Swapnil Hiremath and Managing Editor Cristina Popa discussing selected late-breaking...
Kidney International® Uremia and parathyroid hormone have distinct effects on bone protein and gene expression People with chronic kidney disease (CKD) remain at high risk of fractures despite treatment aimed at maintaining parathyroid hormone at acceptable levels. This study examined the distinct effects of uremia and parathyroid hormone on bone in patients on hemodialysis and controls. The authors...
Kidney International® Modern challenges in infection prevention: encapsulated organisms in the era of novel complement inhibitors This mini review examines infection prevention in patients receiving novel complement inhibitors, with a focus on serious infections caused by encapsulated organisms. It outlines practical strategies, including vaccination, antibiotic prophylaxis, and patient education. The authors stress that these therapies offer important benefits...
Kidney International® A single-arm phase 2 trial of an investigational RNA therapeutic targeting complement factor B (sefaxersen) for treatment of IgA nephropathy IgA nephropathy (IgAN) involves activation of the complement alternative pathway, contributing to kidney inflammation and disease progression. In this global, open-label phase 2 trial, patients with biopsy-confirmed IgAN received sefaxersen, an antisense inhibitor of complement factor B, to...
Every nephrologist has encountered a case that stayed with them, one that challenged assumptions, raised new questions, or changed how they approach care. Turning that experience into a case report is not about including every detail, but about sharing the clinical lesson that others can apply. Submit your case report to KICR Kidney International Case Reports™...
Kidney International® A randomized controlled trial evaluated the effect of pravastatin on kidney disease outcomes in adult patients with early-stage autosomal dominant polycystic kidney disease This randomized, double-blind trial evaluated whether pravastatin could slow disease progression in adults with early autosomal dominant polycystic kidney disease (ADPKD) and preserved kidney function. Researchers followed 150 participants receiving pravastatin or a placebo...
Who can access the evidence that informs practice, and how quickly does that evidence reach the bedside? As Kidney International Reports® (KIR) celebrates its 10th anniversary throughout 2026, these two questions are as pertinent as ever for clinicians and researchers working in kidney care. Reflections from KIR’s Editor-in-Chief Jai Radhakrishnan and Deputy Editor Sumit Mohan highlight how the journal’s editorial decisions, including a commitment to open access and a focus on practice-relevant research, have supported wider access...
Kidney International® Establishing a core outcome measure for life participation in children with chronic kidney disease: A Standardized Outcomes in Nephrology—children and adolescents with chronic kidney disease (SONG-Kids) consensus workshop report Life participation is a priority for children with chronic kidney disease (CKD), yet it is rarely measured consistently in pediatric CKD trials. Through international consensus workshops involving patients,...
Case reports are often where progress begins. A single patient, an unexpected presentation, a practical clinical lesson that sharpens judgment and sparks discussion, ultimately leading to improved understanding and care. With the recent launch of the ISN’s new fully open-access journal, Kidney International Case Reports™ (KICR)*, there has never been a better time to share bedside observations with the global kidney care community. Submit a...
Kidney International® Strategies for the development of sodium-glucose cotransporter-2 inhibitors for kidney protection in pediatric chronic kidney disease: proceedings of a workshop meeting in July 2023 There are currently no approved therapies to slow chronic kidney disease (CKD) progression across the diverse causes of pediatric CKD, despite evidence that sodium–glucose cotransporter-2 inhibitors (SGLT2is) slow kidney disease...
A recent Kidney International® editorial showcases the ISN-Global Kidney Health Atlas (ISN-GKHA) Interactive Map, an open-access tool that enables clinicians, researchers, policymakers, and advocates to identify gaps and target areas where kidney care improvements are most needed. Read the full paper in Kidney International® Consolidating data from the 2019 and 2023 ISN-GKHA surveys, the map: Compares kidney care capacity between countries and regions Tracks trends and measures progress over time Visualizes key indicators like workforce, infrastructure, and policies Provides evidence to guide research, advocacy, and policy initiatives Explore...
Kidney International® Executive summary of the KDIGO 2026 Clinical Practice Guideline for the Management of Anemia in Chronic Kidney Disease (CKD) The KDIGO 2026 guideline updates the management of anemia in CKD in light of new evidence and emerging therapies since the 2012 update. It provides evidence-based recommendations on diagnosis and treatment, including iron therapy, erythropoiesis-stimulating agents, hypoxia-inducible factor–prolyl hydroxylase inhibitors,...
Visual featured in the KIR editorial on its 10th anniversary To mark 10 years of the ISN Journal Kidney International Reports® (KIR), we spoke with Editor-in-Chief Jai Radhakrishnan and Deputy Editor Sumit Mohan about the journal’s origins, defining moments, and how its mission has evolved over the past decade. Explore all ISN Journals Creating a home for...
Kidney International® (KI) introduces a new article type — “Clinical Journey in Translational Medicine” — spotlighting patient cases that link bedside observations to underlying mechanisms of disease. Submissions are now open This concise feature bridges clinical nephrology and discovery science, revealing how individual cases can advance understanding of pathophysiology, diagnostics, or treatment. “The patient’s journey is ultimately what it’s all about. “Clinical Journey in...
Kidney International® Implementing the commitments of the WHO Kidney Health Resolution: Initial steps in three diverse settings Chronic kidney disease (CKD) affects 850 million people globally, with the highest burden in low- and middle-income countries. The WHA78 kidney health resolution offers a unique opportunity to advance prevention and care. This editorial presents case studies from Guatemala, Thailand,...
December 1, 2025 The International Society of Nephrology (ISN) is proud to announce the launch of Kidney International Case Reports (KICR), a new peer-reviewed, open-access journal dedicated to publishing high-quality case reports, focused reviews, and short clinical communications relevant to kidney care. An official ISN Journal, KICR joins Kidney International®, Kidney International Reports®, and Kidney International...
Kidney International® APOL1 kidney disease: Conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference APOL1 genetic variants increase the risk of progressive chronic kidney disease among people of African ancestry. A 2024 KDIGO Controversies Conference reviewed current evidence and debated terminology, testing, and management approaches. Participants agreed on using the term “APOL1 kidney disease,” but found...
