Kidney International® Measuring Albuminuria or Proteinuria: Does One Answer Fit All? The authors review international guideline recommendations on measuring proteinuria and albuminuria and discuss contexts where the optimal measure of proteinuria is unclear or controversial. They discuss evidence to support current recommendations for choice of measure, including the clinical settings of glomerulonephritis, transplantation, and pregnancy. They also...
Precision medicine framework for optimizing CKD treatment Kidney International® Trends and Perspectives for Improving Quality of Chronic Kidney Disease Care: Conclusions From a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference The conference discussed improving chronic kidney disease (CKD) diagnosis, care safety, and patient well-being, identifying current tools, barriers, and research needs in CKD management. Discussions acknowledged that...
Kidney International® A Prospective Controlled, Randomized Clinical Trial of Kidney Transplant Recipients Developed Personalized Tacrolimus Dosing Using Model-based Bayesian Prediction In this study, a population pharmacokinetic (PPK) model, incorporating factors such as genetics, age, and hematocrit, was developed and validated to optimize tacrolimus (Tac) dosage for kidney transplant recipients. PPK-based dosing was compared with traditional weight-based dosing....
Best Basic/Translational and Clinical Science publications in Kidney International® - KI-ISN Early-Career Researcher Award Kidney International® and the International Society of Nephrology (ISN) acknowledge the contribution made by our early-career researchers (ECR) across the globe. We would like to recognize their efforts by selecting the four best original research papers published in Kidney International® (2 basic/translational and...
Kidney International® Models of Care to Address Disparities in Kidney Health Outcomes for First Nation People First Nations people in Australia, New Zealand, Canada, and the USA face a higher risk of kidney problems and struggle to get kidney transplants compared to non-Indigenous people. This review identifies studies that created special healthcare programs for First Nations people...
Kidney International® Novel Anemia Therapies in CKD: Conclusions from a KDIGO Controversies Conference The conference, held virtually in December 2021, reviewed new evidence on diagnosing and managing anemia in chronic kidney disease (CKD). The meeting focused on a new class of agents—the hypoxia-inducible factor-prolyl hydroxylase inhibitors (HIF-PHIs). HIF-PHIs are reported to be non-inferior to conventional Erythropoiesis-Stimulating Agents...
Kidney International® Repurposing Drugs for Diseases Associated With Podocyte Dysfunction Due to recent advances in understanding the molecular and cellular mechanisms underlying podocyte injury, there is potential for repurposing already approved therapeutics for treating these disorders. This mini-review explores the complexities of repurposing drugs for kidney treatment, emphasizing the importance of extensive testing, emerging technologies, early intervention,...
Kidney International® Managing the Symptom Burden Associated With Long-term Dialysis: Conclusions From a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference In 2022, patients, doctors, therapists, nurses, pharmacists, and researchers came together at the KDIGO Controversies Conference, “Symptom-Based Complications in Dialysis,” to examine and agree on essential ideas about recognizing and treating symptoms in dialysis patients....
Kidney International ® Editorial Selections The Power of “Negative” Experiments: Harry Goldblatt’s Pathway to Discovering How Renal Ischemia Causes Hypertension The author demonstrates that Harry Goldblatt’s willingness to conduct and publish studies with negative outcomes led to a fundamental understanding of blood pressure control within less than a decade of his initial discovery, published in...
Kidney International® Effects of Newer Kidney Protective Agents on Kidney Endpoints Provide Implications for Future Clinical Trials The study assesses the effects of newer kidney protective agents on endpoints, including smaller proportional declines in eGFR, to compare relative event rates and the magnitude of observed treatment effects. They found that in populations at high risk of CKD...
Last week, Clarivate’s Journal Citation Reports (JCR) released the 2022 Impact Factors (IF). Kidney International® (KI) remains the top-ranked nephrology journal publishing original research, and Kidney International Reports® (KIR) is the top-ranked open-access nephrology journal. IFs and ranks in the JCR urology and nephrology category: KI’s 2022 Impact Factor is 19.6. It ranks 3/88 journals in the...
Kidney International® has partnered with members of the ISN Emerging Leaders 2022 Program* (ISN-ELP 2022) to launch a series of mini reviews on green nephrology. Read the editorial here. "Green Nephrology: A Series of Mini Reviews on Minimizing the Environmental Impact of Kidney Health Care" aims to: Increase awareness of the environmental impact of health care within the...
Kidney International®: Water Implications in Dialysis Therapy, Threats and Opportunities to Reduce Water Consumption: A Call for the Planet This review summarizes the significant environmental impact of dialysis and provides some suggestions on priorities and potential action. Seeking to support policymakers in making informed decisions about water use, the authors highlight the importance of circular water management...
The GREEN-K Steering Committee is pleased to announce the Global Environmental Evolution in Nephrology and Kidney Care – GREEN-K initiative. This is an international, joint activity of leading national and regional kidney societies on environmentally sustainable kidney care through advocating for and educating in green nephrology to reduce the specialty's carbon footprint. Find out more about...
Kidney International® The ASCEND-NHQ Randomized Trial Found Positive Effects of Daprodustat on Hemoglobin and Quality of Life in Patients With Non-Dialysis Chronic Kidney Disease This clinical trial administered a daily daprodustat or a placebo pill to 614 patients with CKD and anemia for 28 weeks. People treated with daprodustat had a larger increase in hemoglobin and less...
Kidney International® Editorial Selection Perspectives on Early Detection of CKD: The Facts, the Questions, and a Proposed Framework for 2023 and Beyond To guide stakeholders on whether to establish early detection and intervention programs for CKD, an ISN working group examines whether the benefits of early-detection programs outweigh the cost and potential moral hazard. The authors encourage...
Watch the latest ISN video abstracts from the @ISNeducation Social Media Team. Watch the videos here. The videos are based on papers from Kidney International® and Kidney International Reports®: A Novel Direct Adenosine Monophosphate Kinase Activator Ameliorates Disease Progression in Preclinical Models of Autosomal Dominant Polycystic Kidney Disease Transitional B cell Cytokines Risk Stratify Early Borderline Rejection After Renal...
Kidney International Improving and Maintaining Quality of Hemodialysis in Areas Affected by War: A Call to Action In this “Nephrologists Sans Frontières” section of KI, Alasfar and colleagues discuss the long-term implications of the Syrian war on the delivery of renal replacement therapy in affected regions. They propose several strategies to manage the situation, including creativity in...
As the global burden of chronic kidney disease (CKD) rises, “Perspectives on Early Detection of CKD: The Facts, the Questions, and a Proposed Framework for 2023 and Beyond” presents timely information from ISN leaders on early CKD detection and a framework for adoption. Read the paper in Kidney International here. This paper culminates two years of work that...
Kidney International KDIGO Conference Report on Home Dialysis Controversies The Kidney Disease: Improving Global Outcomes (KDIGO) conference, held in May 2021, sought to address the global underutilization of home dialysis therapies and identify approaches and strategies to expand their use. The conference also addressed the financial implications of home dialysis and how best to improve the...
