Kidney International® A Toolkit for ISN’s Registry Initiative, SharE-RR This paper, led by Fergus J. Caskey, chair of the ISN SharE-RR Advisory Group, in collaboration with other SharE-RR Advisory Group members and global registry experts, introduces the ISN SharE-RR toolkit developed to assist in establishing renal registries. Access the ISN SharE-RR toolkit here The toolkit, informed by existing...
Kidney International® Executive Summary of the KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease: Known Knowns and Known Unknowns This executive summary of the Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease outlines the bases for updated therapies and strategies...
Kidney International® Executive Summary of the KDIGO 2024 Clinical Practice Guideline for the Management of ANCA-Associated Vasculitis Since the 2021 Kidney Disease: Improving Global Outcomes (KDIGO) Guideline for the Management of Glomerular Diseases was published, important data concerning anti-neutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) has become available. These include the regulatory approval of avacopan for ANCA-AAV...
Kidney International® Kidney Biopsies Among Persons Living in Hotspots of Ckdu: A Position Statement From the International Society of Nephrology’s Consortium of Collaborators on Ckdu Chronic kidney disease of unknown etiology (CKDu) remains a significant problem in several regions around the world. The ISN conducted meetings and surveys to assess the need for kidney biopsies in...
Submit your manuscript here by July 31, 2024 Kidney International Reports® will publish a dedicated issue on mitochondrial function in diabetic kidney disease (DKD) later this year. Understanding mitochondrial dynamics and metabolism is crucial for therapeutic advancements in DKD. This special issue will offer a detailed exploration of these aspects through original research and comprehensive reviews. Find...
Kidney International® Providing Environmentally Sustainable Nephrology Care: Focus in Low- and Middle-income Countries This article is part of the series "Green Nephrology: A Series of Mini-Reviews on Minimizing the Environmental Impact of Kidney Health Care," a collaboration between Kidney International® and members of the ISN Emerging Leaders 2022 Program. To help reduce the need for costly and environmentally...
Kidney International® Living Kidney Donors’ Healthcare Needs, Experiences and Perspectives Across Their Entire Donation Trajectory: A Semi-Structured, In-depth Interview Study This qualitative descriptive study examined the experiences of living kidney donors (LKDs) throughout care. It aimed to identify gaps in information and care as LKDs transitioned through different phases. The results reveal gaps in post-donation care for...
Kidney International® Conservative Kidney Management and Kidney Supportive Care: Core Components of Integrated Care for People with Kidney Failure The ISN Conservative Kidney Management/Kidney Supportive Care Workgroup (CKM/KSC) is one of five thematic workgroups formed as part of the ISN’s 5 to 10-year strategy for the integrated care of individuals with kidney failure, involving collaboration with...
Kidney International® Executive Summary of the KDIGO 2024 Clinical Practice Guideline for the Management of Lupus Nephritis The Kidney Disease: Improving Global Outcomes (KDIGO) has updated its Glomerular Diseases Guideline for lupus nephritis (LN) in response to accelerated drug development and new insights from genetic and molecular studies. Read the updated guideline here The most significant change involves...
Best Basic/Translational and Clinical Science publications in Kidney International® - KI-ISN Early-Career Researcher Award Kidney International® and the International Society of Nephrology (ISN) acknowledge the contribution made by our early-career researchers (ECR) across the globe. We would like to recognize their efforts by selecting the four best original research papers published in Kidney International® (2 basic/translational and...
Kidney International® Mayo Clinic Consensus Report on Membranous Nephropathy: Proposal for a Novel Classification This report proposes a two-step classification of membranous nephropathy (MN). Step one is identifying the target antigen based on a multistep algorithm. The second step is the search for a potential underlying disease or associated condition. The meeting consensus favored using an antigen-based...
Kidney International® Measuring Albuminuria or Proteinuria: Does One Answer Fit All? The authors review international guideline recommendations on measuring proteinuria and albuminuria and discuss contexts where the optimal measure of proteinuria is unclear or controversial. They discuss evidence to support current recommendations for choice of measure, including the clinical settings of glomerulonephritis, transplantation, and pregnancy. They also...
Precision medicine framework for optimizing CKD treatment Kidney International® Trends and Perspectives for Improving Quality of Chronic Kidney Disease Care: Conclusions From a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference The conference discussed improving chronic kidney disease (CKD) diagnosis, care safety, and patient well-being, identifying current tools, barriers, and research needs in CKD management. Discussions acknowledged that...
Kidney International® A Prospective Controlled, Randomized Clinical Trial of Kidney Transplant Recipients Developed Personalized Tacrolimus Dosing Using Model-based Bayesian Prediction In this study, a population pharmacokinetic (PPK) model, incorporating factors such as genetics, age, and hematocrit, was developed and validated to optimize tacrolimus (Tac) dosage for kidney transplant recipients. PPK-based dosing was compared with traditional weight-based dosing....
Kidney International® Models of Care to Address Disparities in Kidney Health Outcomes for First Nation People First Nations people in Australia, New Zealand, Canada, and the USA face a higher risk of kidney problems and struggle to get kidney transplants compared to non-Indigenous people. This review identifies studies that created special healthcare programs for First Nations people...
Kidney International® Novel Anemia Therapies in CKD: Conclusions from a KDIGO Controversies Conference The conference, held virtually in December 2021, reviewed new evidence on diagnosing and managing anemia in chronic kidney disease (CKD). The meeting focused on a new class of agents—the hypoxia-inducible factor-prolyl hydroxylase inhibitors (HIF-PHIs). HIF-PHIs are reported to be non-inferior to conventional Erythropoiesis-Stimulating Agents...
Kidney International® Repurposing Drugs for Diseases Associated With Podocyte Dysfunction Due to recent advances in understanding the molecular and cellular mechanisms underlying podocyte injury, there is potential for repurposing already approved therapeutics for treating these disorders. This mini-review explores the complexities of repurposing drugs for kidney treatment, emphasizing the importance of extensive testing, emerging technologies, early intervention,...
Kidney International® Managing the Symptom Burden Associated With Long-term Dialysis: Conclusions From a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference In 2022, patients, doctors, therapists, nurses, pharmacists, and researchers came together at the KDIGO Controversies Conference, “Symptom-Based Complications in Dialysis,” to examine and agree on essential ideas about recognizing and treating symptoms in dialysis patients....
Kidney International ® Editorial Selections The Power of “Negative” Experiments: Harry Goldblatt’s Pathway to Discovering How Renal Ischemia Causes Hypertension The author demonstrates that Harry Goldblatt’s willingness to conduct and publish studies with negative outcomes led to a fundamental understanding of blood pressure control within less than a decade of his initial discovery, published in...
Kidney International® Effects of Newer Kidney Protective Agents on Kidney Endpoints Provide Implications for Future Clinical Trials The study assesses the effects of newer kidney protective agents on endpoints, including smaller proportional declines in eGFR, to compare relative event rates and the magnitude of observed treatment effects. They found that in populations at high risk of CKD...
