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ISN Journal Editorial Selections

Kidney International®

A Prospective Controlled, Randomized Clinical Trial of Kidney Transplant Recipients Developed Personalized Tacrolimus Dosing Using Model-based Bayesian Prediction 

In this study, a population pharmacokinetic (PPK) model, incorporating factors such as genetics, age, and hematocrit, was developed and validated to optimize tacrolimus (Tac) dosage for kidney transplant recipients.

PPK-based dosing was compared with traditional weight-based dosing. Patients in the PPK group achieved target Tac levels sooner, experienced less intra-patient variability, and required fewer dose adjustments within the first 90 days post-transplant.

This study paves the way for improving Tac dosage in organ transplantation, potentially enhancing patient care and clinical outcomes.


Kidney International Reports®

Epidemiology and Outcomes of Children with Kidney Failure Receiving Kidney Replacement Therapy in Australia and New Zealand

Kidney replacement therapy (KRT) incidence and outcomes have been extensively researched in adults, while studies in children have been comparatively limited.

This study used data from the Australia and New Zealand Dialysis and Transplant Registry to describe the epidemiology and outcomes of KRT in children and adolescents in these countries between 2000 and 2020.

The findings indicate that peritoneal dialysis is the predominant choice for kidney replacement therapy (KRT) among Australasian children. Notably, patient survival, technique survival, and graft survival rates are outstanding, with graft survival showing notable improvement over the past two decades.




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