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Precision medicine framework for optimizing CKD treatment
The conference discussed improving chronic kidney disease (CKD) diagnosis, care safety, and patient well-being, identifying current tools, barriers, and research needs in CKD management.
Discussions acknowledged that tools for diagnosing and treating CKD have expanded since the previous (2012) guideline. Although more opportunities for improvement are anticipated, conclusions suggest that care delivery needs to be adapted, particularly in terms of patient experiences, to take full advantage of these advances. In addition, there is a need for more research on blood and urine biomarkers and molecular phenotyping.
This study investigates the relationship between soluble urokinase plasminogen activation receptor (suPAR) levels and cardiovascular outcomes in a cohort of 4994 individuals with chronic kidney disease (CKD) to determine whether the suPAR-CKD association depends on the severity of CKD.
SuPAR was positively correlated with age, kidney function, and other factors,
and suPAR levels were independently associated with all-cause death, cardiovascular death, and major cardiovascular events regardless of diabetes status, kidney function, or other factors.