ISN-ACT Global Trials Focus Subgroup member Maria Chiara Pelle summarizes the design and outcomes of one of the ISN-ACT Global Trials Focus’ latest trial selections. Read all the latest global trial selections from the ISN-ACT initiative here. The “trial of the month” is available in several languages. Letermovir vs Valganciclovir for Prophylaxis of Cytomegalovirus in High-risk Kidney Transplant...
Kidney International® A Prospective Controlled, Randomized Clinical Trial of Kidney Transplant Recipients Developed Personalized Tacrolimus Dosing Using Model-based Bayesian Prediction In this study, a population pharmacokinetic (PPK) model, incorporating factors such as genetics, age, and hematocrit, was developed and validated to optimize tacrolimus (Tac) dosage for kidney transplant recipients. PPK-based dosing was compared with traditional weight-based dosing....
To stay updated on the latest research and developments in kidney care, access the latest selection of global trials from the ISN-ACT initiative here in multiple languages. ISN-ACT Global Trials Focus Coordinator Michele Provenzano summarizes the design and outcomes of the ISN-ACT Global Trials Focus’ latest “Trial of the Month.” Balanced Crystalloid Solution Versus Saline in...
The 2023 ISN-Global Kidney Health Atlas (ISN-GKHA) is driving positive change in kidney care on a global scale, and you can play a role in this transformation! Assessing global kidney care: ISN-GKHA's comprehensive analysis for informed health policies The ISN-GKHA is a comprehensive resource offering an overview of the current readiness, capacity, and competence for kidney...
Anastasiia Zykova, ISN Advancing Clinical Trials Network member, summarizes the design and outcomes of a study from the ISN-ACT Global Trials Focus' most recent global trials selection. Evaluation of a simple, low-cost intervention to empower people with chronic kidney disease to reduce their dietary salt intake: OxCKD1, a multi-center randomized controlled trial. Summary In this trial, 193 adult participants...
The newly updated ISN iNET-CKD Network cohorts map features a new layout, revised information on cohorts, and additional data. Access the ISN iNET-CKD Network cohorts map here. The ISN iNET-CKD Network is one-of-a-kind. It tracks ongoing chronic kidney disease (CKD) cohort studies located worldwide, facilitating an exchange of insights into CKD progression and its global implications. This network's...
Kidney International® Repurposing Drugs for Diseases Associated With Podocyte Dysfunction Due to recent advances in understanding the molecular and cellular mechanisms underlying podocyte injury, there is potential for repurposing already approved therapeutics for treating these disorders. This mini-review explores the complexities of repurposing drugs for kidney treatment, emphasizing the importance of extensive testing, emerging technologies, early intervention,...
Nikolay Bulanov, ISN-ACT Global Trials Focus Subgroup member, summarizes the design and outcomes of a study from the ISN-ACT Global Trials Focus' most recent global trials selection and comments on the trial's limitations. A randomized clinical trial assessing the effect of automated medication-targeted alerts on acute kidney injury outcomes Summary: In this parallel-group, pragmatic, open-label trial, 5060 hospitalized...
Kidney International® Managing the Symptom Burden Associated With Long-term Dialysis: Conclusions From a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference In 2022, patients, doctors, therapists, nurses, pharmacists, and researchers came together at the KDIGO Controversies Conference, “Symptom-Based Complications in Dialysis,” to examine and agree on essential ideas about recognizing and treating symptoms in dialysis patients....
The "Regional Variation in Hemoglobin Distribution Among Individuals With CKD: the ISN International Network of CKD Cohorts" study, led by ISN iNET-CKD* investigators, addresses anemia's global prevalence in people living with chronic kidney disease (CKD). Read the manuscript here. Current guidelines suggest a uniform hemoglobin (Hb) range for all people with CKD, but this research examines...
Michele Provenzano summarizes the design and outcomes of the ISN-ACT Global Trials Focus’ latest “Trial of the Month” and comments on possible mechanisms of the benefit and limitations of the results. A CONVINCE-ing trial for Hemodiafiltration Effect of Hemodiafiltration or Hemodialysis on Mortality in Kidney Failure Reviewed by Dr. Provenzano, ISN-ACT Global Trials Focus Subgroup...
Watch the webinar “Winning Steps for a Successful WCN’24 Abstract Submission and Beyond.” It’s abstract submission season! How can you write a good abstract that will get accepted to WCN’24? WCN’24 abstract reviewers Sabine Karam, Magdalena Madero, Roberto Pecoits-Filho and Rob Walker have got you covered! Follow their foolproof advice on writing a winning abstract...
The ISN-Global Kidney Health Atlas (ISN-GKHA) team has produced region-specific summary slides from the 2023 ISN-GKHA edition. Access the documents* here: Africa, Eastern and Central Europe, Latin America, Middle East, NIS and Russia, North America and the Caribbean, North and East Asia, Oceania and South East Asia, South Asia, Western Europe. Why are these slides useful? This...
Kidney International ® Editorial Selections The Power of “Negative” Experiments: Harry Goldblatt’s Pathway to Discovering How Renal Ischemia Causes Hypertension The author demonstrates that Harry Goldblatt’s willingness to conduct and publish studies with negative outcomes led to a fundamental understanding of blood pressure control within less than a decade of his initial discovery, published in...
Download This infographic was supported by an unrestricted educational grant from AstraZeneca
Download This infographic was supported by an unrestricted educational grant from Travere Therapeutics
Fergus Caskey, chair of the ISN Research Working Group, interviews ISN President Masaomi Nangaku and immediate Past President Agnes Fogo on the first guidance for the optimal conduct of translational animal studies for developing new drugs to treat kidney disease. Listen to the ISN Global Kidney Care Podcast here. Learn about: The initiative’s goal of improving translational...
The ISN-ACT Clinical Trials Toolkit, launched in 2020, is designed to guide anyone starting a clinical trial or participating as a trial site. This user-friendly online toolkit is for nephrologists and researchers in kidney care from all parts of the world – regardless of their level of clinical trial experience or local resources. The toolkit includes...
ISN i3C Network members and ISN staff at one of the recently held "Work in Progress" meetings The ISN i3C (CKDu) Network (International Consortium CKDu Collaborators) brought together more than 80 participants at two online interactive meetings held in June and July to discuss current, notable work on chronic kidney disease of unknown origin (CKDu). In...
Kidney International® has published the "International Society of Nephrology First Consensus Guidance for Pre-clinical Animal Studies in Translational Nephrology." This open-access paper was developed from the "First Consensus Meeting on Guidance for Optimal Pre-Clinical Animal Studies in Translational Nephrology" (TRANSFORM) hosted by the ISN in Brussels, Belgium, in October 2022. This is the first such guidance. The recommendations...
