Research

Sleep-HD Trial Results: The Quest Continues for an Effective Therapy For Insomnia in Hemodialysis Patients

Read all global trial selections from the ISN-ACT initiative here. The “trial of the month” is available in several languages. In addition, selected clinical trials are demystified for the layperson. ISN-ACT Global Trials Focus editorial team member Megan Borkum summarizes the design and outcomes of one of the ISN-ACT Global Trials Focus’s latest trial selections. Effectiveness...

Latest ISN Journal Editorial Selections

Kidney International® Home Dialysis:  Conclusions From a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference In May 2021, KDIGO held a conference on expanding home dialysis emphasizing the need for policy alignment, resources, and shared decision-making between patients, care partners, and healthcare teams to improve access and use. The conference stressed the need to advocate for...

Discover the Newly Reviewed ISN-ACT Clinical Trials Toolkit With New Content!

The ISN-ACT Clinical Trials Toolkit is designed to guide anyone starting a clinical trial or participating as a trial site. It is aimed at nephrologists and researchers in kidney care worldwide, regardless of their level of clinical trial experience or local resources. The toolkit includes contributions from over 25 ISN-ACT Toolkit subgroup members – –...

Latest ISN Journal Editorial Selections

Kidney International® Improving and Maintaining Quality of Hemodialysis in Areas Conflicted by War: A Call to Action! Alasfar and colleagues discuss the severe impact of the Syrian war on kidney replacement therapy in the region, highlighting logistical challenges and compromised standards of care. They suggest key strategies to help manage kidney care in conflict areas, including understanding...

Clinical Trial on Different Fluids for Kidney Transplantation Summarized for the Layperson

A new trial has been added to the  “ISN Global Kidney Trials Insights: A Guide for Everyone.” Read the guide on balanced crystalloid solution versus saline in deceased donor kidney transplantation. The guide is based on the ISN-ACT Global Trials Focus (GTF) summaries. It aims to demystify clinical trials for the layperson, providing clear and accessible explanations of...

Explore the ISN Global Trials Focus Selection for February and March, Featuring a “Trial of the Month” on the Efficacy and Safety of Aldosterone Synthase Inhibition 

ISN-ACT Global Trials Focus editorial team member Neeru Agarwal summarizes the design and outcomes of the latest ISN-ACT Global Trials Focus "Trial of the Month."  The "Trial of the Month" is available in several languages, now including German. Read all global trial selections from the ISN-ACT initiative here. In addition, selected clinical trials are demystified for the layperson.  Part of the...

Explore Global Variance in Kidney Care Capacity: Papers Summarizing ISN-GKHA Regional Data Published in Kidney International® Supplements

The 2023 ISN Global Kidney Health Atlas (GKHA) sheds light on the current global capacity to deliver kidney care. Read the Kidney International® Supplements papers here A collection of papers published in Kidney International® Supplements focuses on each of the ten ISN regions, presenting a comprehensive overview of kidney care services by world region. They highlight...

Sharing Expertise to Establish Renal Registries Worldwide: Read the ISN SharE-RR Publication Introducing Its Toolkit

The ISN Sharing Expertise to Support the Set-up of Renal Registries (ISN SharE-RR) initiative develops resources to help establish or develop renal registries in emerging countries. Find more information on SharE-RR here The SharE-RR Advisory Group has created a step-by-step toolkit to guide nephrologists, public health officials, and others to establish and maintain successful, sustainable renal...

Protecting IgA Nephropathy Patients: Sparsentan Reduces Proteinuria and Preserves Kidney Function Through to Two Years

ISN-ACT Global Trials Focus editorial team member Neeru Agarwal summarizes the design and outcomes of one of the ISN-ACT Global Trials Focus's latest trial selections. Read all global trial selections from the ISN-ACT initiative here. The "trial of the month" is available in several languages. In addition, selected clinical trials are demystified for the layperson. Efficacy and safety...

A Ray of Light for People Living With Chronic Kidney Disease: A Promising Digital Physical Activity Intervention

ISN-ACT Global Trials Focus editorial team member Megan Borkum summarizes the design and outcomes of one of the ISN-ACT Global Trials Focus's latest trial selections. Read all global trial selections from the ISN-ACT initiative here. The "trial of the month" is available in several languages. In addition, selected clinical trials are demystified for the layperson. Evaluating the effect...

Sparsentan Decreased Proteinuria, but Failed to Slow eGFR Decline in FSGS: Data From the DUPLEX Trial – New Selection of Global Trials Out Now!

ISN-ACT Global Trials Focus Subgroup member Anastasiia Zykova summarizes the design and outcomes of the team's latest "Trial of the Month." Stay updated on the latest research and developments in kidney care: Access the new selection of global trials from the ISN-ACT initiative here. The "Trial of the Month" is available in several languages. Sparsentan Versus Irbesartan...

The Lancet Global Health Publishes ISN Paper on Global Insights From the 2023 ISN-Global Kidney Health Atlas

The paper "An Update on the Global Disparities in Kidney Disease Burden and Care Across World Countries and Regions" has been published in The Lancet Global Health. Read the paper here. In the same edition, The Lancet Global Health published an editorial on the paper: "The Major Global Burden of Chronic Kidney Disease." Read the editorial...

Expanding Skills and Knowledge in Key Areas of Kidney Care: Access Three New ISN Implementation Toolkits

As part of the ISN-WHO 2021-2023 collaboration plan, the ISN is pleased to announce the release of three new implementation toolkits. The ISN thanks all experts involved for their outstanding contributions. Acute Kidney Injury (AKI) Toolkit The toolkit facilitates AKI detection, management, and prevention, integrating key strategies highlighted in the ISN 0by25 initiative. Access here The toolkit was developed...

“An Essential Advocacy Tool That Young Nephrologists Should Wholeheartedly Endorse”: Yannick Nlandu on the ISN-Global Kidney Health Atlas

By Yannick Nlandu (DR Congo), YNC member and  ISN-GKHA Named Fellow   Most nephrologists dream of solving kidney health problems in their communities, typically requiring a more generalist approach to public health. However, nephrology programs in general, and in low-resource countries in particular, do not integrate this broad vision of kidney health. Nephrologists, therefore, need to...

Demystifying Global Kidney Trials: Providing Clear Explanations for All With a New ISN Patient-Focused Initiative

Discover the "ISN Global Kidney Trials Insights: A Guide for Everyone," a new ISN initiative for people living with kidney diseases and others interested in kidney-related clinical trials. The project intends to foster meaningful communication between patients and kidney care practitioners and increase patient participation in clinical trials. Read the first study in the guide comparing...

What is the ISN Doing About the Challenge of Chronic Kidney Disease of Unknown Origin?

Despite ongoing efforts, chronic kidney disease of unknown origin (CKDu) remains a significant, persistent challenge in several world regions. As part of its commitment to advancing equitable kidney care worldwide, the ISN launched the ISN i3C (CKDu) Network at WCN 2017 to facilitate global CKDu-related collaboration and data collection and dissemination. Explore the details of...

“Integral in Enabling Me to Start My Research Career”: ISN Clinical Research Program Facilitates Groundbreaking Study on Dialysis in Zimbabwe

Rumbidzai Dahwa received an ISN Clinical Research Program (CRP) grant for the research project "Prevalence of Chronic Kidney Disease in Zimbabwe" in 2017. Find out more about the CRP and how to apply here. The study, completed in 2020, was the first to provide comprehensive data on the nature and prevalence of dialysis in Zimbabwe and...

Tackling the CKDu Puzzle: Read the ISN i3C Working Group’s Position Statement on Kidney Biopsies

Despite ongoing efforts, chronic kidney disease of unknown origin (CKDu) remains a significant, persistent problem in several world regions. The ISN i3C (CKDu) Working Group has written a comprehensive position statement offering vital guidance and recommendations for kidney biopsies in individuals suspected of CKDu. Read "Kidney Biopsies Among Persons Living in Hotspots of CKDu: A...