Research

A Ray of Light for People Living With Chronic Kidney Disease: A Promising Digital Physical Activity Intervention

ISN-ACT Global Trials Focus editorial team member Megan Borkum summarizes the design and outcomes of one of the ISN-ACT Global Trials Focus's latest trial selections. Read all global trial selections from the ISN-ACT initiative here. The "trial of the month" is available in several languages. In addition, selected clinical trials are demystified for the layperson. Evaluating the effect...

Sparsentan Decreased Proteinuria, but Failed to Slow eGFR Decline in FSGS: Data From the DUPLEX Trial – New Selection of Global Trials Out Now!

ISN-ACT Global Trials Focus Subgroup member Anastasiia Zykova summarizes the design and outcomes of the team's latest "Trial of the Month." Stay updated on the latest research and developments in kidney care: Access the new selection of global trials from the ISN-ACT initiative here. The "Trial of the Month" is available in several languages. Sparsentan Versus Irbesartan...

The Lancet Global Health Publishes ISN Paper on Global Insights From the 2023 ISN-Global Kidney Health Atlas

The paper "An Update on the Global Disparities in Kidney Disease Burden and Care Across World Countries and Regions" has been published in The Lancet Global Health. Read the paper here. In the same edition, The Lancet Global Health published an editorial on the paper: "The Major Global Burden of Chronic Kidney Disease." Read the editorial...

Expanding Skills and Knowledge in Key Areas of Kidney Care: Access Three New ISN Implementation Toolkits

As part of the ISN-WHO 2021-2023 collaboration plan, the ISN is pleased to announce the release of three new implementation toolkits. The ISN thanks all experts involved for their outstanding contributions. Acute Kidney Injury (AKI) Toolkit The toolkit facilitates AKI detection, management, and prevention, integrating key strategies highlighted in the ISN 0by25 initiative. Access here The toolkit was developed...

“An Essential Advocacy Tool That Young Nephrologists Should Wholeheartedly Endorse”: Yannick Nlandu on the ISN-Global Kidney Health Atlas

By Yannick Nlandu (DR Congo), YNC member and  ISN-GKHA Named Fellow   Most nephrologists dream of solving kidney health problems in their communities, typically requiring a more generalist approach to public health. However, nephrology programs in general, and in low-resource countries in particular, do not integrate this broad vision of kidney health. Nephrologists, therefore, need to...

Demystifying Global Kidney Trials: Providing Clear Explanations for All With a New ISN Patient-Focused Initiative

Discover the "ISN Global Kidney Trials Insights: A Guide for Everyone," a new ISN initiative for people living with kidney diseases and others interested in kidney-related clinical trials. The project intends to foster meaningful communication between patients and kidney care practitioners and increase patient participation in clinical trials. Read the first study in the guide comparing...

What is the ISN Doing About the Challenge of Chronic Kidney Disease of Unknown Origin?

Despite ongoing efforts, chronic kidney disease of unknown origin (CKDu) remains a significant, persistent challenge in several world regions. As part of its commitment to advancing equitable kidney care worldwide, the ISN launched the ISN i3C (CKDu) Network at WCN 2017 to facilitate global CKDu-related collaboration and data collection and dissemination. Explore the details of...

“Integral in Enabling Me to Start My Research Career”: ISN Clinical Research Program Facilitates Groundbreaking Study on Dialysis in Zimbabwe

Rumbidzai Dahwa received an ISN Clinical Research Program (CRP) grant for the research project "Prevalence of Chronic Kidney Disease in Zimbabwe" in 2017. Find out more about the CRP and how to apply here. The study, completed in 2020, was the first to provide comprehensive data on the nature and prevalence of dialysis in Zimbabwe and...

Tackling the CKDu Puzzle: Read the ISN i3C Working Group’s Position Statement on Kidney Biopsies

Despite ongoing efforts, chronic kidney disease of unknown origin (CKDu) remains a significant, persistent problem in several world regions. The ISN i3C (CKDu) Working Group has written a comprehensive position statement offering vital guidance and recommendations for kidney biopsies in individuals suspected of CKDu. Read "Kidney Biopsies Among Persons Living in Hotspots of CKDu: A...

The ISN Applauds Ten New ISN-Named Fellows

Please join us in congratulating: Michele Provenzano for ISN-ACT (clinical trials) Anna Strasma for ISN i3C CKDu (chronic kidney disease of unknown origin) Winston Fung, Anukul Ghimire, Georgina Irish, Sabine Karam, Yannick Nlandu, Anna Petrova, Samveg Shah and Elliot Tannor for ISN-GKHA (Global Kidney Health Atlas) Get to know our ISN-Named Fellows here. These early-career ISN members were approved as...

ENVISION-ing a New Way Forward in IgA Nephropathy A Phase 2 Trial of Sibeprenlimab 

Daniel O’Hara, ISN-ACT Global Trials Focus coordinator, summarizes the design and outcomes of the latest "Trial of the Month." Explore all the global trial selections for November and December here. The "Trial of the Month" is available in several languages. A Phase 2 Trial of Sibeprenlimab in Patients With IgA Nephropathy Mathur et al., N Engl J Med...

Efficacy of Gravity-driven Continuous Flow Peritoneal Dialysis in Children

Rupesh Raina, ISN-ACT Global Trials Focus Subgroup member, summarizes the design and outcomes of one of the team's latest trial selections. Read all the latest global trial selections from the ISN-ACT initiative here. The "Trial of the month" is available in several languages. Gravity-assisted Continuous Flow Peritoneal Dialysis Technique Use in Acute Kidney Injury in Children: A...

Latest ISN Journal Editorial Selections

Precision medicine framework for optimizing CKD treatment Kidney International® Trends and Perspectives for Improving Quality of Chronic Kidney Disease Care: Conclusions From a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference  The conference discussed improving chronic kidney disease (CKD) diagnosis, care safety, and patient well-being, identifying current tools, barriers, and research needs in CKD management. Discussions acknowledged that...

Structured Delivery of Cognitive Behavioural Therapy and Targeted Symptom Management Can Improve Fatigue, Pain and Depression Among Those on Dialysis

Daniel O’Hara, the ISN-ACT Global Trials Focus coordinator, summarizes the design and outcomes of one of the team’s latest trial selections. Read all the latest global trial selections from the ISN-ACT initiative here. The “trial of the month” is available in several languages. Effects of Technology-assisted Stepped Collaborative Care Intervention to Improve Symptoms in Patients Undergoing Hemodialysis:...

Letermovir Non-inferior to Valganciclovir for CMV Prophylaxis, With Lower Leukopenia Rates

ISN-ACT Global Trials Focus Subgroup member Maria Chiara Pelle summarizes the design and outcomes of one of the ISN-ACT Global Trials Focus’ latest trial selections. Read all the latest global trial selections from the ISN-ACT initiative here. The “trial of the month” is available in several languages. Letermovir vs Valganciclovir for Prophylaxis of Cytomegalovirus in High-risk Kidney Transplant...

ISN Journal Editorial Selections

Kidney International® A Prospective Controlled, Randomized Clinical Trial of Kidney Transplant Recipients Developed Personalized Tacrolimus Dosing Using Model-based Bayesian Prediction  In this study, a population pharmacokinetic (PPK) model, incorporating factors such as genetics, age, and hematocrit, was developed and validated to optimize tacrolimus (Tac) dosage for kidney transplant recipients. PPK-based dosing was compared with traditional weight-based dosing....

Balanced Crystalloid Fluids May Reduce Delayed Graft Function in Deceased Donor Kidney Transplantation – New Selection of Global Trials Out Now

To stay updated on the latest research and developments in kidney care, access the latest selection of global trials from the ISN-ACT initiative here in multiple languages. ISN-ACT Global Trials Focus Coordinator Michele Provenzano summarizes the design and outcomes of the ISN-ACT Global Trials Focus’ latest “Trial of the Month.” Balanced Crystalloid Solution Versus Saline in...

The 2023 ISN-GKHA: Shaping the Future of Kidney Health Worldwide – Access Region-specific Data and Use the Findings in Your Research

The 2023 ISN-Global Kidney Health Atlas (ISN-GKHA) is driving positive change in kidney care on a global scale, and you can play a role in this transformation! Assessing global kidney care: ISN-GKHA's comprehensive analysis for informed health policies The ISN-GKHA is a comprehensive resource offering an overview of the current readiness, capacity, and competence for kidney...