Journals

The ISN launches Kidney International Case Reports: Shaping clinical practice in global kidney care through real-world insights

December 1, 2025 The International Society of Nephrology (ISN) is proud to announce the launch of Kidney International Case Reports (KICR), a new peer-reviewed, open-access journal dedicated to publishing high-quality case reports, focused reviews, and short clinical communications relevant to kidney care. An official ISN Journal, KICR joins Kidney International®, Kidney International Reports®, and Kidney International...

December 1, 2025Journals, NewsRead more...

ISN Journal summaries on APOL1 kidney disease and expanding peritoneal dialysis in India 

Kidney International®   APOL1 kidney disease: Conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference  APOL1 genetic variants increase the risk of progressive chronic kidney disease among people of African ancestry. A 2024 KDIGO Controversies Conference reviewed current evidence and debated terminology, testing, and management approaches.   Participants agreed on using the term “APOL1 kidney disease,” but found...

November 24, 2025Journals, NewsRead more...

Kidney International® publishes new CKD remission paradigm, presented simultaneously at Kidney Week 2025

Kidney International® (KI) published "From progression to remission: a new paradigm for success in chronic kidney disease," by Nav Tangri, David Cherney, Katherine Tuttle, and Vlado Perkovic. The article was released at the same time as its presentation at ASN Kidney Week, increasing the study's visibility and reinforcing its significance to the global kidney community.  Read the article in KI  The research emphasizes a shift in...

November 10, 2025Journals, NewsRead more...

ISN Journal summaries on kidney transplantation in patients with plasma cell dyscrasia and gender differences in living kidney donation 

Kidney International®   Management recommendations for kidney transplantation in patients with plasma cell dyscrasia  Patients with plasma cell dyscrasia such as multiple myeloma and AL amyloidosis often develop kidney failure but have been underrepresented in kidney transplantation due to recurrence risk and poor outcomes. A multidisciplinary panel reviewed new evidence showing improved survival with modern therapies and expanding transplant eligibility....

November 10, 2025Journals, NewsRead more...

ISN Emerging Leaders spotlight the role of non-physician health workers in kidney care 

Kidney International Reports® has published a paper from the ISN Emerging Leaders Program (ELP) Cohort 3, “Expanding kidney care: How non-physician health workers can address the global CKD crisis.”   The publication explores how non-physician health workers — such as community health workers and nurses — can help close critical gaps in chronic kidney disease prevention...

October 27, 2025ELP, Grants, JournalsRead more...

ISN Journal summaries on felzartamab for IgA nephropathy and a new anti-podocin ELISA  

Kidney International®   Randomized, double-blind, placebo-controlled phase 2a study assessing the efficacy and safety of felzartamab for IgA nephropathy  A phase 2a trial tested felzartamab, an anti-CD38 antibody, in 54 patients with IgA nephropathy. Patients received different doses of felzartamab or placebo over six months.   Felzartamab reduced protein in the urine, with the strongest and longest-lasting effect seen...

October 27, 2025Journals, News, ResearchRead more...

ISN Journal summaries on the DIALIZE-Outcomes trial and heat stress nephropathy in CKDu hotspots in India 

Kidney International®   The randomized DIALIZE-Outcomes trial evaluated sodium zirconium cyclosilicate in hemodialysis  People on hemodialysis often face dangerous swings in blood potassium that can trigger sudden death or heart rhythm problems.   The DIALIZE-Outcomes trial tested whether the potassium binder sodium zirconium cyclosilicate (SZC) could reduce serious cardiovascular events compared with placebo in 2,690 patients with kidney failure.  The...

October 13, 2025Journals, News, ResearchRead more...

ISN Journal summaries on the KDIGO Guideline on IgAN and IgAV, and urinary dickkopf-3 to predict GFR loss 

Kidney International®   KDIGO 2025 Clinical Practice Guideline for the Management of Immunoglobulin A Nephropathy (IgAN) and Immunoglobulin A Vasculitis (IgAV)  IgA nephropathy and IgA vasculitis are leading causes of kidney disease worldwide, but treatment approaches have long varied.   The KDIGO 2025 guideline consolidates the latest evidence to provide updated recommendations on diagnosis, risk assessment, and therapies, aiming...

September 29, 2025Journals, NewsRead more...

ISN Journal summaries on zigakibart, proteinuria, and pediatric CKD in rural Africa 

Kidney International®   Zigakibart demonstrates clinical safety and efficacy in a Phase 1/2 trial of healthy volunteers and patients with IgA nephropathy  Zigakibart, a humanized monoclonal antibody targeting A Proliferation-Inducing Ligand (APRIL), was tested in healthy volunteers and patients with IgA nephropathy (IgAN) in a Phase 1/2 trial with 100-week follow-up.   The treatment was well tolerated and led...

September 15, 2025Journals, NewsRead more...

ISN Journal summaries on gender-specific kidney health and ethical considerations in CKDu research 

Kidney International®   Women and kidney health: Conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference The conference highlighted key sex- and gender-specific issues in kidney care, emphasizing chronic kidney disease’s (CKD) impact on women’s reproductive health and pregnancy outcomes.   Recommendations included counseling, multidisciplinary pregnancy management, and systematic monitoring of kidney function, blood pressure, and proteinuria.   The...

September 1, 2025Journals, NewsRead more...

ISN Journal summaries on MGRS risk prediction and CKD screening 

Kidney International®  The Mayo MGRS Prediction Tool calculates the risk of finding monoclonal gammopathy of renal significance in a kidney biopsy in patients with monoclonal gammopathy   Determining which patients with chronic kidney disease (CKD) and monoclonal gammopathy should undergo a kidney biopsy to diagnose monoclonal gammopathy of renal significance (MGRS) remains a clinical challenge.  Researchers developed and...

July 28, 2025Journals, NewsRead more...

ISN journal summaries on maternal preeclampsia and CKD medication safety during breastfeeding    

Kidney International®  A nationwide register-based cohort study examined the association between preeclampsia in mothers and the risk of kidney disease in their offspring  A large cohort study of over 2.2 million births has found that children born at term to mothers with preeclampsia face a higher risk of developing kidney disease later in life.  The study revealed...

July 14, 2025Advocacy, Journals, NewsRead more...

ISN Journal summaries on the SONG initiative and public data in research 

Kidney International®  The Standardized Outcomes in Nephrology (SONG) initiative: A decade of harmonizing patient voices and research in kidney disease   The authors of this editorial highlight how research on chronic kidney disease has been hindered by inconsistent and often patient-irrelevant reporting of outcomes.   This challenge prompted the launch of the global Standardized Outcomes in Nephrology (SONG) initiative...

June 30, 2025Journals, NewsRead more...

ISN Journal summaries on membranous nephropathy and disaster management

Kidney International® Designing clinical trials for the treatment of membranous nephropathy in the anti-PLA2R era: Results of a NephCure membranous nephropathy workshop Membranous nephropathy (MN) is a leading cause of adult nephrotic syndrome, and anti-PLA2R antibodies are now recognized as key biomarkers reflecting disease activity in many patients. At a 2023 NephCure workshop, experts discussed how to...

May 26, 2025Journals, NewsRead more...

ISN Journal summaries on nephrotic syndrome in children and obesity’s role in CKD 

Kidney International®  Executive summary of the KDIGO 2025 Clinical Practice Guideline for the Management of Nephrotic Syndrome in Children  The 2025 KDIGO executive summary updates guidance on managing nephrotic syndrome in children, introducing a treatment algorithm and aligning definitions with international standards.   It revises relapse prevention strategies, recommends against routine steroid use during infections, and emphasizes personalized...

May 12, 2025Journals, NewsRead more...

ISN Journal summaries on CONVINCE trial findings and kidney transplantation in Iran 

Kidney International®  A health economic evaluation of the multinational, randomized controlled CONVINCE trial: cost-utility of high-dose online hemodiafiltration compared to high-flux hemodialysis  Patients with kidney failure often receive either high-flux hemodialysis (HD) or high-dose hemodiafiltration (HDF). Previous research shows HDF may lower the risk of death compared to HD.   This study looked at whether the potential health...

April 28, 2025Journals, News, ResearchRead more...

KIR publishes on findings from the ISN Western Europe Regional Board survey on preferred meeting formats 

Kidney International Reports® (KIR) has published as an article-in-press the results of a survey conducted by the ISN Western Europe Regional Board on preferred scientific meeting formats— in-person, virtual, or hybrid.   Explore the survey findings in KIR   “Nephrology health professionals' perspectives on their preferred modality for scientific meetings, balancing affordability, sustainability and opportunities to interact...

April 7, 2025Journals, News, Regional Activities, ResearchRead more...

ISN Journal summaries on IgA nephropathy and conservative kidney management

Kidney International®  Treatment of patients with IgA nephropathy: a call for a new paradigm  Current treatments for IgA nephropathy (IgAN), including supportive care and corticosteroids, have limited success and significant side effects.   Advances in understanding IgAN’s pathogenesis have led to new targeted therapies and a proposed dual approach: targeting IgAN-specific mechanisms (e.g., pathogenic IgA production) and managing...

April 7, 2025Journals, NewsRead more...

ISN Journal summaries on CKD-MBD, Pexivas trial, in-center hemodialysis, and the ISN Collaborative Quality Framework on Dialysis 

Kidney International® (KI)  Chronic Kidney Disease–Mineral and Bone Disorder: Conclusions From a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference  The 2023 KDIGO conference confirmed that the 2017 guidelines on managing chronic kidney disease–mineral and bone disorder (CKD-MBD) remain valid but proposed reframing CKD-MBD around two clinical syndromes: CKD-associated osteoporosis and CKD-associated cardiovascular disease.  Future guidelines may...

March 24, 2025Journals, NewsRead more...

ISN Journal summaries on World Kidney Day  

Kidney International® (KI)  Are Your Kidneys OK? Detect Early to Protect Kidney Health  The  World Kidney Day (WKD) editorial in Kidney International highlights the importance of early kidney disease detection to protect kidney health, slow progression, and reduce cardiovascular risk. Simple tests — serum creatinine and urine albumin — enable early diagnosis, but barriers like funding...

March 10, 2025Journals, News, World Kidney DayRead more...