The ISN-ACT (Advancing Clinical Trials) and NephJC are partnering to increase awareness of ongoing trials in nephrology and improve understanding of what it takes to design and conduct clinical trials, especially in terms of different trial designs. The ISN-ACT produces the Global Trials Focus, a monthly list that identifies and summarizes recent interesting trials relevant...
The ISN-Advancing Clinical Trials (ISN-ACT) initiative developed the paper, “The International Society of Nephrology Advancing Clinical Trials (ISN-ACT) Network: current activities and future goals,” which is now available in the December edition of Kidney International (KI). The manuscript highlights the need for high-quality clinical trials in the field of nephrology. It outlines the ISN-ACT network’s...
The paper, “Availability and Affordability of Kidney Health Laboratory Tests around the Globe,” has been published in the American Journal of Nephrology. The manuscript, produced by the KDIGO Controversies Conference leaders in collaboration with ISN, surveyed a representative subset of ISN-Global Kidney Health Atlas (ISN-GKHA) respondents from April to June 2020 to ascertain the availability and...
The ISN had an exciting start to research projects in 2020 with the Research Collaborative Meeting and 1ST International Consensus Meeting on Defining Kidney Failure in Clinical Trials that took place from January 31 - February 1 in Vancouver, Canada. The ISN convened this international, multi-stakeholder meeting to develop consensus on definitions of kidney failure...
The ISN Executive Committee and Council have approved four “ISN-Named Fellows.” These ISN members – early-career nephrologists – have contributed significantly to various outputs of ISN’s research activities. Find out more about these ISN-Named Fellows here. ISN GKHA Fellow – Isabelle Ethier Dr. Isabelle Ethier from Centre Hospitalier de l’Université de Montréal (Canada) has been awarded the title...
The American Journal of Nephrology (AJN) has published the ISN-KDIGO manuscript, “Availability and Affordability of Kidney Health Laboratory Tests Around the Globe.” Read the full, open-access article here. Laboratory testing of kidney health measures is essential to diagnose and monitor kidney diseases. The availability and affordability of kidney health laboratory tests across countries remain largely undefined. The...
Every month the ISN-ACT Team lists interesting new randomized controlled trials (RCTs) from around the world. Highlight: Corticosteroids and cyclophosphamide may be superior to tacrolimus and rituximab in the treatment of primary membranous nephropathy at the cost of increased adverse events See the latest trials here. A summary of the highlighted trial is now available in French, Mandarin,...
The ISN Global Kidney Health Atlas (GKHA) aims to improve understandings of inter-and intra-national variability worldwide in terms of the capacity to deliver care for patients with kidney diseases. The 2019 GKHA survey used the WHO universal health coverage (UHC) domains, which summarize and compare the availability, accessibility, and affordability of high-quality care for patients...
Every month the ISN-ACT Team lists interesting new randomized controlled trials (RCTs) from around the world. Highlight: SGLT-2 inhibition strikes again Dapagliflozin in Patients with Chronic Kidney Disease See the latest trials here. A summary of the highlighted trial is now available in French, Mandarin, and Spanish. Support equal access to nephrology research: Become an ISN Member!
The ISN i3C (International Consortium CKDu Collaborators) group developed the ISN Observatory of CKDu as part of its Collaboration Plan with the World Health Organization (WHO) to facilitate information exchange and raise awareness of the urgent issue of Chronic Kidney Disease of unknown etiology. Collating ongoing studies and efforts on CKDu provides a valuable overview...
Every month the ISN-ACT Team lists interesting new randomized controlled trials (RCTs) from around the world. Highlight: LOL-HD study: Laughter therapy may reduce depressive symptoms in hemodialysis patients See the latest trials here. A summary of the highlighted trial is now available in French, Spanish, and Mandarin. Support equal access to nephrology research: Become an ISN Member!
The webinar, Gathering Wisdom: SGLT2i in Diabetic and Non-Diabetic Kidney Diseases, will be held on November 9, 2020, at 3 p.m. CET. This symposium will focus on the current state of therapeutic options for CKD and DKD, with specific attention to accumulating evidence of recent SGLT2i trials. The webinar is supported by an unrestricted educational grant by AstraZeneca. Registration details will follow shortly.
The ISN-ACT Clinical Trials Toolkit is an open-access, online resource to assist trial design, study conduct, data management, data analysis, and publication. More than ever, clinical trials in nephrology are needed to generate high-quality evidence to inform all aspects of care for patients with or at risk of kidney disease, including those affected by COVID-19. Access...
Every month the ISN-ACT Team lists interesting new randomized controlled trials from around the world. Highlight: Diltiazem may be superior to nifedipine for post-partum hypertension in pregnancy. See the latest trials here. From October 2020, the GTF will be available in French, Spanish, Arabic, and Mandarin. Would you like to support equal access to nephrology research? Become an ISN...
Dr. Rolando Claure Del Granado and colleagues involved in the ISN 0by25 initiative in Bolivia Every year, the Scientific Committee of the Medical College of Bolivia awards outstanding studies and investigators that significantly impact the local population. This year, the jury recognized the academic and research activities of Dr. Rolando Claure Del Granado and selected the...
The ISN-ACT Global Trials Focus team has collected and published a new list of randomized research from nephrologists around the world for August 2020. Each trial is reviewed in context and the risk of bias in seven key areas is assessed. Highlight: Allopurinol does not slow the progression of chronic kidney disease in patients with type 1...
The full DAPA-CKD trial results will be presented and reviewed at the ESC Congress 2020, Sunday, August 30, 17:00 – 17:30 CET. Topic Renal failure and Cardiovascular Disease Chairpersons Rory Collins (Oxford, UK); Frank Ruschitzka (Zurich, Switzerland) Presentations: DAPA-CKD – Dapagliflozin in Patients with CKD: Hiddo Heerspink (Groningen, Netherlands) DAPA- CKD – Live Prime Discussion: Diederick E Grobbee (Utrecht, Netherlands) Q&A Session The...
The ISN invites nephrologists to register patients affected by COVID-19 on the new global COVID registry. The ISN collaborated with the University of Cambridge to develop CORONATION, the Coronavirus multinational observational registry, a data entry portal accessible to nephrologists worldwide to collect anonymous data on individual people with kidney disease and the COVID-19 infection. For more information, please visit...
Kidney International will shortly publish the International Consensus Definitions of Clinical Trial Outcomes for Kidney Failure: 2020, developed from the 1st International Consensus Meeting on Defining Kidney Failure in Clinical Trials hosted by the ISN in Vancouver, BC, Canada, in early 2020. This is the first attempt by the international nephrology community to identify reproducible,...
Every month the ISN-ACT Team lists interesting new randomized controlled trials from around the world. Highlight: Early ACE-inhibition is safe in pediatric Alport’s Syndrome and may be effective See the latest trials here
