ISN Journal summaries on the DIALIZE-Outcomes trial and heat stress nephropathy in CKDu hotspots in India
Kidney International®
The randomized DIALIZE-Outcomes trial evaluated sodium zirconium cyclosilicate in hemodialysis
People on hemodialysis often face dangerous swings in blood potassium that can trigger sudden death or heart rhythm problems.
The DIALIZE-Outcomes trial tested whether the potassium binder sodium zirconium cyclosilicate (SZC) could reduce serious cardiovascular events compared with placebo in 2,690 patients with kidney failure.
The trial ended early due to fewer cardiovascular events than expected and many participants stopping treatment. It showed no difference in major outcomes, but SZC improved potassium control and had a safety profile similar to placebo.
Kidney International Reports®
Heat stress nephropathy in CKD of uncertain etiology hotspots of Bargarh District Odisha, India
Repeated heat exposure and dehydration can damage kidneys, but community-level evidence is scarce.
This cross-sectional study of over 1,100 people in Odisha, India, found that heat stress nephropathy was common among farmers, especially in areas with the highest heat stress index.
Elevated dehydration markers and kidney biopsies showing tubulointerstitial nephritis confirmed heat stress as a likely contributor to chronic kidney disease of uncertain etiology in this region.
