Research

ISN Journal summaries on felzartamab for IgA nephropathy and a new anti-podocin ELISA  

Kidney International®   Randomized, double-blind, placebo-controlled phase 2a study assessing the efficacy and safety of felzartamab for IgA nephropathy  A phase 2a trial tested felzartamab, an anti-CD38 antibody, in 54 patients with IgA nephropathy. Patients received different doses of felzartamab or placebo over six months.   Felzartamab reduced protein in the urine, with the strongest and longest-lasting effect seen...

October 27, 2025Journals, News, ResearchRead more...

ISN Journal summaries on the DIALIZE-Outcomes trial and heat stress nephropathy in CKDu hotspots in India 

Kidney International®   The randomized DIALIZE-Outcomes trial evaluated sodium zirconium cyclosilicate in hemodialysis  People on hemodialysis often face dangerous swings in blood potassium that can trigger sudden death or heart rhythm problems.   The DIALIZE-Outcomes trial tested whether the potassium binder sodium zirconium cyclosilicate (SZC) could reduce serious cardiovascular events compared with placebo in 2,690 patients with kidney failure.  The...

October 13, 2025Journals, News, ResearchRead more...

CONFIDENCE trial: Dual therapy shows promise for CKD and diabetes  

ISN-ACT Global Trials Focus (GTF) editorial team member Michele Provenzano summarizes the design and outcomes of the latest “Trial of the month” featured in ISN-ACT GTF.  Trial of the month:  Stronger together: Finerenone & empagliflozin boost kidney outcomes in diabetes  Finerenone with empagliflozin in chronic kidney disease and type 2 diabetes  Agarwal R, et al., N Engl J...

September 15, 2025News, ResearchRead more...

Building momentum in CKDu research: Global experts share progress and insights 

The mystery of chronic kidney disease of unknown origin (CKDu) continues to puzzle researchers, but efforts to solve it are gaining ground. The i3C Network is steadily expanding, bringing together researchers, clinicians, and public health experts with one shared goal: to uncover the causes behind CKDu and protect vulnerable populations.  In July, over 40 experts...

September 1, 2025News, ResearchRead more...

From data to impact: What is it like to be part of ISN research initiatives? 

From global policy tools to community-driven projects and early-career development, ISN's research initiatives offer meaningful opportunities for all professionals committed to advancing kidney care. Whether you're just starting out or looking to broaden your impact, you can grow, collaborate, and drive real impact through ISN-supported research activities. We invited several contributors to share what...

July 28, 2025News, ResearchRead more...

Explore the latest ISN Global Trials Focus selections featuring a “Trial of the month” on the effect of dapagliflozin in patients with ADPKD receiving tolvaptan

ISN-ACT Global Trials Focus editorial team member Michele Provenzano summarizes the design and outcomes of the latest "Trial of the month" featured in ISN-ACT Global Trials Focus. Trial of the month: DAPA-tolvaptan: First trial of SGLT2 inhibition in ADPKD with background tolvaptan therapy Open-label, randomized, controlled, crossover trial on the effect of dapagliflozin in patients with ADPKD receiving tolvaptan Uchiyama...

June 30, 2025News, ResearchRead more...

What does the ISN-GKHA tell us about global dialysis trends?  

Why do millions of people worldwide still face limited access to dialysis despite advances in kidney care?  This urgent question was at the heart of the recent ISN-GKHA webinar: “Global variations in hemodialysis access and outcomes – insights for improving kidney care worldwide,” based on two extensive global studies informed by 2023 ISN-Global Kidney Health...

June 16, 2025News, ResearchRead more...

ISN Journal summaries on making CKD research accessible to patients and pregnancy outcomes in kidney transplant recipients 

Kidney International®  Identifying strategies for disseminating research to patients with chronic kidney disease and caregivers: a workshop report   Research on chronic kidney disease (CKD) is often inaccessible to patients and caregivers, limiting its influence on care and decision-making.   A workshop involving patients, caregivers, and health professionals identified three key strategies to improve dissemination: making research engaging and...

June 16, 2025News, ResearchRead more...

How the ISN-Global Kidney Health Atlas is growing a global community for optimal kidney care

Through robust data collection, international collaboration, and practical insights, the 2023 ISN-Global Kidney Health Atlas (ISN-GKHA) continues to drive progress in kidney care worldwide. This essential resource maps the availability and quality of kidney health services globally, helping kidney care professionals shape policy, support advocacy, guide research priorities, and identify service gaps, all toward...

May 26, 2025News, ResearchRead more...

ISN Journal summaries on CONVINCE trial findings and kidney transplantation in Iran 

Kidney International®  A health economic evaluation of the multinational, randomized controlled CONVINCE trial: cost-utility of high-dose online hemodiafiltration compared to high-flux hemodialysis  Patients with kidney failure often receive either high-flux hemodialysis (HD) or high-dose hemodiafiltration (HDF). Previous research shows HDF may lower the risk of death compared to HD.   This study looked at whether the potential health...

April 28, 2025Journals, News, ResearchRead more...

KIR publishes on findings from the ISN Western Europe Regional Board survey on preferred meeting formats 

Kidney International Reports® (KIR) has published as an article-in-press the results of a survey conducted by the ISN Western Europe Regional Board on preferred scientific meeting formats— in-person, virtual, or hybrid.   Explore the survey findings in KIR   “Nephrology health professionals' perspectives on their preferred modality for scientific meetings, balancing affordability, sustainability and opportunities to interact...

April 7, 2025Journals, News, Regional Activities, ResearchRead more...

ISN-GKHA 2023 findings feature in PLOS Global Public Health roundtable 

PLOS Global Public Health recently hosted a roundtable with the lead authors of ISN-Global Kidney Health Atlas (ISN-GKHA) articles they published earlier this year.  The authors highlight key insights from their research, which examined disparities in the availability, affordability, quality, and access to kidney care services across countries categorized by World Bank income group classifications.   Watch...

April 7, 2025News, ResearchRead more...

Optimize trial integrity: New SOP and ethics resources in the ISN-ACT Clinical Trials Toolkit 

The ISN-ACT Toolkit now features a section on Standard Operating Procedures (SOPs) in clinical trials to help improve clarity, consistency, and traceability in clinical trial processes.   Access the SOP section of the ISN Clinical Trials Toolkit here  Contributed by ISN-Advancing Clinical Trials Committee member Paula Andrea Marioli (Argentina) and colleagues, the section includes:  Suggested SOP format – a structured guide...

March 24, 2025News, ResearchRead more...

Explore the latest ISN-ACT Global Trials Focus selection featuring a “Trial of the Month” on the role of targeted exercises for children on hemodialysis  

ISN-ACT Global Trials Focus editorial team member Neeru Agarwal summarizes the design and outcomes of the latest "Trial of the Month" featured in ISN-ACT Global Trials Focus.   Trial of the Month:  Effect of muscle stretching and isometric exercises on quality of life in children undergoing regular hemodialysis  Khalf-Allah et al., Pediatric Nephrology. 2024 39:3289-3299.  Summary  In this single-center study, 68...

March 10, 2025News, ResearchRead more...

Global kidney health visualized: Explore the ISN-GKHA interactive map 

Launched at WCN’25, the ISN-Global Kidney Health Atlas (ISN-GKHA) interactive map is a powerful visual tool to explore comprehensive global kidney health data from the 2019 and 2023 ISN-GKHA reports. This interactive, searchable platform highlights key trends currently shaping kidney health and care with the potential to drive improvements worldwide.   Explore global kidney health...

February 24, 2025News, ResearchRead more...

PLOS articles spotlight ISN-GKHA 2023 findings on the international state of kidney care

PLOS Global Public Health recently published a series of articles using data from the third edition of the ISN-Global Kidney Health Atlas (ISN-GKHA), exploring gaps in availability, affordability, quality, and access to kidney care services across countries by World Bank income group classifications.  Read the individual papers in PLOS Global Public Health:   “Landscape of kidney replacement...

February 24, 2025News, ResearchRead more...

ISN’s Global Kidney Health Atlas 2023 Data Addresses Kidney Care Gaps in Resource-limited Settings

PLOS Global Public Health recently published a series of articles using data from the third edition of the ISN-Global Kidney Health Atlas (ISN-GKHA), exploring gaps in availability, affordability, quality, and access to kidney care services across countries by World Bank income group classifications. Read the individual papers in PLOS Global Public Health: “Landscape of Kidney Replacement...

February 12, 2025News, ResearchRead more...

Is Semaglutide a Game-changer for CKD? Insights for the Layperson Into the SMART Trial in the “Guide for Everyone”

The “ISN Global Kidney Trials Insights: A Guide for Everyone,” inspired by the ISN-ACT Global Trials Focus summaries, translates complex trial findings into accessible information. This initiative empowers people living with kidney disease and their caregivers to better understand advancements in kidney care. Access all the simplified summaries here. The latest case study features the SMART...

January 21, 2025News, ResearchRead more...

ISN Journal Summaries on Hypertension-avoidance Strategies and Age-based GFR    

Kidney International®  A Sub-study of the POISE-3 Randomized Trial Examined Effects of a Perioperative Hypotension-avoidance Strategy Versus a Hypertension-avoidance Strategy on the Risk of Acute Kidney Injury  This sub-study of the POISE-3 trial investigated whether a strategy to prevent low blood pressure during surgery could reduce the risk of acute kidney injury (AKI).   Researchers randomized 7,307 patients...

January 6, 2025Journals, News, ResearchRead more...