Despite ongoing efforts, chronic kidney disease of unknown origin (CKDu) remains a significant, persistent problem in several world regions. The ISN i3C (CKDu) Working Group has written a comprehensive position statement offering vital guidance and recommendations for kidney biopsies in individuals suspected of CKDu. Read "Kidney Biopsies Among Persons Living in Hotspots of CKDu: A...
Please join us in congratulating: Michele Provenzano for ISN-ACT (clinical trials) Anna Strasma for ISN i3C CKDu (chronic kidney disease of unknown origin) Winston Fung, Anukul Ghimire, Georgina Irish, Sabine Karam, Yannick Nlandu, Anna Petrova, Samveg Shah and Elliot Tannor for ISN-GKHA (Global Kidney Health Atlas) Get to know our ISN-Named Fellows here. These early-career ISN members were approved as...
By Andrea Viecelli As this year's chair of the ISN Young Nephrologists Committee's Capacity Building Sub-Committee, I had the opportunity to lead an amazing team of young kidney health professionals to build capacity and improve leadership skills, clinical workforce management, and research. Young nephrologists, particularly those practicing in low-income countries, have consistently acknowledged research as a...
Ensure you're well-equipped in the global effort to combat kidney diseases by exploring, utilizing and sharing these valuable ISN resources. CKD Early Identification & Intervention Toolkit To address the burden of chronic kidney disease (CKD) and its impact on global morbidity, the ISN and KDIGO collaborated on a series of tools for CKD early identification and...
Modules 5 and 6 of the CME-accredited ISN YNC Curriculum: Basics of Statistics for a Successful Start in Clinical Research are now available at the ISN Academy. Access Modules 5 and 6 now! (Join/renew your ISN membership to access this content) Module 5: Learn the applications of big data and machine learning in clinical research through...
Rupesh Raina, ISN-ACT Global Trials Focus Subgroup member, summarizes the design and outcomes of one of the team's latest trial selections. Read all the latest global trial selections from the ISN-ACT initiative here. The "Trial of the month" is available in several languages. Gravity-assisted Continuous Flow Peritoneal Dialysis Technique Use in Acute Kidney Injury in Children: A...
Precision medicine framework for optimizing CKD treatment Kidney International® Trends and Perspectives for Improving Quality of Chronic Kidney Disease Care: Conclusions From a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference The conference discussed improving chronic kidney disease (CKD) diagnosis, care safety, and patient well-being, identifying current tools, barriers, and research needs in CKD management. Discussions acknowledged that...
From left to right: Caner Alparslan, ISN Young Nephrologists Committee member (Turkey); SWC faculty members Rümeyza Kazancioğlu (Turkey), Hans Peter Marti (Norway), and Zdenka Hruskova (Czech Republic); and host and BANTAO president Mustafa Arici (Turkey)* The ISN held a Scientific Writing Course (SWC) in Istanbul from October 5-7 at Istanbul University's central campus. During the three-day...
ISN-ACT Global Trials Focus Subgroup member Maria Chiara Pelle summarizes the design and outcomes of one of the ISN-ACT Global Trials Focus’ latest trial selections. Read all the latest global trial selections from the ISN-ACT initiative here. The “trial of the month” is available in several languages. Letermovir vs Valganciclovir for Prophylaxis of Cytomegalovirus in High-risk Kidney Transplant...
Kidney International® A Prospective Controlled, Randomized Clinical Trial of Kidney Transplant Recipients Developed Personalized Tacrolimus Dosing Using Model-based Bayesian Prediction In this study, a population pharmacokinetic (PPK) model, incorporating factors such as genetics, age, and hematocrit, was developed and validated to optimize tacrolimus (Tac) dosage for kidney transplant recipients. PPK-based dosing was compared with traditional weight-based dosing....
The ISN is delighted to announce the results of its latest grant application period. We are pleased to welcome participants from fifteen countries worldwide: Six new ISN Fellows who will receive training to help them establish or improve local care in their home regions. The awardees are from Fiji, Kenya, Nigeria, the Solomon Islands and...
To stay updated on the latest research and developments in kidney care, access the latest selection of global trials from the ISN-ACT initiative here in multiple languages. ISN-ACT Global Trials Focus Coordinator Michele Provenzano summarizes the design and outcomes of the ISN-ACT Global Trials Focus’ latest “Trial of the Month.” Balanced Crystalloid Solution Versus Saline in...
The 2023 ISN-Global Kidney Health Atlas (ISN-GKHA) is driving positive change in kidney care on a global scale, and you can play a role in this transformation! Assessing global kidney care: ISN-GKHA's comprehensive analysis for informed health policies The ISN-GKHA is a comprehensive resource offering an overview of the current readiness, capacity, and competence for kidney...
Anastasiia Zykova, ISN Advancing Clinical Trials Network member, summarizes the design and outcomes of a study from the ISN-ACT Global Trials Focus' most recent global trials selection. Evaluation of a simple, low-cost intervention to empower people with chronic kidney disease to reduce their dietary salt intake: OxCKD1, a multi-center randomized controlled trial. Summary In this trial, 193 adult participants...
The newly updated ISN iNET-CKD Network cohorts map features a new layout, revised information on cohorts, and additional data. Access the ISN iNET-CKD Network cohorts map here. The ISN iNET-CKD Network is one-of-a-kind. It tracks ongoing chronic kidney disease (CKD) cohort studies located worldwide, facilitating an exchange of insights into CKD progression and its global implications. This network's...
Kidney International® Repurposing Drugs for Diseases Associated With Podocyte Dysfunction Due to recent advances in understanding the molecular and cellular mechanisms underlying podocyte injury, there is potential for repurposing already approved therapeutics for treating these disorders. This mini-review explores the complexities of repurposing drugs for kidney treatment, emphasizing the importance of extensive testing, emerging technologies, early intervention,...
Nikolay Bulanov, ISN-ACT Global Trials Focus Subgroup member, summarizes the design and outcomes of a study from the ISN-ACT Global Trials Focus' most recent global trials selection and comments on the trial's limitations. A randomized clinical trial assessing the effect of automated medication-targeted alerts on acute kidney injury outcomes Summary: In this parallel-group, pragmatic, open-label trial, 5060 hospitalized...
Whether taking your first steps into clinical research or looking to improve your statistical skills, the ISN Young Nephrologists Committee's six-part video curriculum guides you to use statistics effectively and analyze and interpret data from clinical trials and studies. Access Chapter I, Modules 1 and 2 now! Module 1: Learn study design basics and the...
The "Regional Variation in Hemoglobin Distribution Among Individuals With CKD: the ISN International Network of CKD Cohorts" study, led by ISN iNET-CKD* investigators, addresses anemia's global prevalence in people living with chronic kidney disease (CKD). Read the manuscript here. Current guidelines suggest a uniform hemoglobin (Hb) range for all people with CKD, but this research examines...
Michele Provenzano summarizes the design and outcomes of the ISN-ACT Global Trials Focus’ latest “Trial of the Month” and comments on possible mechanisms of the benefit and limitations of the results. A CONVINCE-ing trial for Hemodiafiltration Effect of Hemodiafiltration or Hemodialysis on Mortality in Kidney Failure Reviewed by Dr. Provenzano, ISN-ACT Global Trials Focus Subgroup...
